NP_001623.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53.9 kDa
NCBI Official Full Name
alkaline phosphatase, placental type preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Protein Information
alkaline phosphatase, placental type
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
UniProt Synonym Gene Names
NCBI Summary for ALPP
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
UniProt Comments for ALPP
MiscellaneousIn most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
Research Articles on ALPP
Precautions
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Disclaimer
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Products associated with ALPP active protein
Pathways associated with ALPP active protein
Diseases associated with ALPP active protein
Organs/Tissues associated with ALPP active protein
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