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AIF1 recombinant protein :: Allograft Inflammatory Factor 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143756 AIF1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,585 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Allograft Inflammatory Factor 1 (AIF1), Recombinant Protein

 Also Known As   

Recombinant Human Allograft Inflammatory Factor 1

 Product Synonym Names    AIF1 Human; Allograft Inflammatory Factor 1 Human Recombinant; AIF-1; Allograft inflammatory factor 1; Em:AF129756.17; G1; IBA1; Ionized calcium-binding adapter molecule 1; IRT-1; Protein G1; AIF1
 Product Gene Name   

AIF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601833
 3D Structure    ModBase 3D Structure for P55008
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS PAGE.
 Form/Format    Filtered and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl pH-7.5.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
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 Preparation and Storage    For long term, store lyophilized AIF1 at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.The lyophilized protein remains stable for 24 months when stored at -20 degree C.
 Other Notes    Small volumes of AIF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AIF1 recombinant protein

   Description: The AIF1 Human Recombinant contains a total of 155 amino acids having a molecular Mass of 17.7kDa. The Human AIF1 is fused to a 9 amino acid long N-terminal His tag.

Introduction: Human AIF1 protein shares 98% homology/identity with that of rat. AIF1 is expressed in macrophages and neutrophils. The expression of AIF1 transcripts is upregulated by IFN-g in rat macrophages. AIF1 is expressed selectively in human macrophage-like cell lines, and in a subset of CD68(+) macrophages in the interstitial and perivascular spaces of human heart allografts. In quiescent cultured human vascular smooth muscle cells synthesis of AIF1 is induced by IFN-g, IL1b, and conditioned medium of T-cells. Overexpression of AIF1 in human VSMCs results in enhanced growth of these cells. AIF1 is expressed during apoptosis rat mammary gland and ventral prostate tissues. Allograft Inflammatory Factor 1 is expressed by several tumor-associated activated macrophages and microglial cells in rat and human gliomas. There is an evident relationship of AIF1-expressing activated macrophages and microglial cells with tumor malignancy in humans.
 Product Categories/Family for AIF1 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines
NCBI/Uniprot data below describe general gene information for AIF1. It may not necessarily be applicable to this product.
 NCBI GI #    14574568
 NCBI GeneID    199
 NCBI Accession #    NP_001614.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001623.3 [Other Products]
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 UniProt Primary Accession #    P55008 [Other Products]
 UniProt Secondary Accession #    O43904; Q9UIV4; Q9UKS9; A8K406 [Other Products]
 UniProt Related Accession #    P55008 [Other Products]
 Molecular Weight    14,617 Da
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 NCBI Official Full Name    allograft inflammatory factor 1 isoform 3
 NCBI Official Synonym Full Names    allograft inflammatory factor 1
 NCBI Official Symbol    AIF1 [Similar Products]
 NCBI Official Synonym Symbols   
IBA1; IRT1; AIF-1; IRT-1
[Similar Products]
 NCBI Protein Information    allograft inflammatory factor 1; allograft inflammatory factor-1 splice variant Hara-1; interferon gamma responsive transcript; ionized calcium-binding adapter molecule 1; protein G1
 UniProt Protein Name    Allograft inflammatory factor 1
 UniProt Synonym Protein Names   
Ionized calcium-binding adapter molecule 1; Protein G1
 Protein Family    Apoptosis-inducing factor
 UniProt Gene Name    AIF1 [Similar Products]
 UniProt Synonym Gene Names    G1; IBA1; AIF-1 [Similar Products]
 UniProt Entry Name    AIF1_HUMAN
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 NCBI Summary for AIF1    This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for AIF1    AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; actin filament; perikaryon; nucleus; cytosol; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; microglial cell activation; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; response to axon injury; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; inflammatory response; response to electrical stimulus; negative regulation of apoptosis
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 Research Articles on AIF1    1. AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AIF1 recombinant proteinPathways associated with AIF1 recombinant protein
 Reference Product  PubMed Publications
 GFAP recombinant protein  >101 publications with AIF1 and GFAP
 RAC1 recombinant protein  >4 publications with AIF1 and RAC1
 TYROBP recombinant protein  >2 publications with AIF1 and TYROBP
 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with AIF1 recombinant proteinOrgans/Tissues associated with AIF1 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >280 publications with AIF1 and Disease Models, Animal
 Inflammation Antibodies  >157 publications with AIF1 and Inflammation
 Death Antibodies  >115 publications with AIF1 and Death
 Cardiovascular Diseases Antibodies  >99 publications with AIF1 and Cardiovascular Diseases
 Necrosis Antibodies  >93 publications with AIF1 and Necrosis
 Nerve Degeneration Antibodies  >43 publications with AIF1 and Nerve Degeneration
 Neurotoxicity Syndromes Antibodies  >17 publications with AIF1 and Neurotoxicity Syndromes
 Cognition Disorders Antibodies  >16 publications with AIF1 and Cognition Disorders
 Edema Antibodies  >13 publications with AIF1 and Edema
 Parkinson Disease Antibodies  >13 publications with AIF1 and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >423 publications with AIF1 and Brain
 Blood Antibodies  >144 publications with AIF1 and Blood
 Vascular Antibodies  >62 publications with AIF1 and Vascular
 Muscle Antibodies  >48 publications with AIF1 and Muscle
 Bone Marrow Antibodies  >40 publications with AIF1 and Bone Marrow
 Eye Antibodies  >32 publications with AIF1 and Eye
 Embryonic Tissue Antibodies  >19 publications with AIF1 and Embryonic Tissue
 Heart Antibodies  >18 publications with AIF1 and Heart
 Liver Antibodies  >15 publications with AIF1 and Liver
 Spleen Antibodies  >14 publications with AIF1 and Spleen
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