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SERPINA1 recombinant protein :: Alpha-1 Antitrypsin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144889 SERPINA1 recombinant protein
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,075 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-1 Antitrypsin (SERPINA1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Alpha-1 Antitrypsin, Active

 Product Synonym Names    SERPINA1 Human, Active; Alpha-1 Antitrypsin, Active Human Recombinant; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; SERPINA1; A1AT; PI; A1A; AAT; PI1; MGC9222; PRO2275; MGC23330; SERPINA1, Active
 Product Gene Name   

SERPINA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107400
 3D Structure    ModBase 3D Structure for P01009
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 Host    Rice Grain (Oryza Sativa)
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    SERPINA1 was lyophilized from a concentrated solution containing recombinant Albumin.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized SERPINA1 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    3~5 mg SERPINA1 will inhibit 1 mg PPE with an activity of 10.8 units per mg protein
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 Preparation and Storage    Lyophilized SERPINA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution SERPINA1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of SERPINA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SERPINA1 recombinant protein

   Description: SERPINA1 Human Recombinant produced in rice is a single, non-glycosylated polypeptide chain containing 384 amino acids and having a molecular mass of 43.1 kDa.The SERPINA1 protein is purified by proprietary chromatographic techniques.

Introduction: SERPINA1 is secreted and is a serine protease inhibitor which its targets include elastase, plasmin, collagenase, thrombin, leucocytic proteases, trypsin, chymotrypsin, and plasminogen activator. Defects in SERPINA1 gene can cause emphysema or liver disease. Antral SERPINA1 expression is particularly induced by H. pylori infection. lung and prostate cancers have shown a significant increase in SERPINA1 serum levels compared with healthy controls though breast cancers did not show a significant change. SERPINA1 is an endogenous inhibitor of serine proteases and inhibits the catalytic domain of human recombinant matriptase in vitro. Rise in SERPINA1 occurs as an acute phase response to tissue necrosis and inflammation. mutations in SERPINA1 and SLC11A1 genes change the balance between elastase produced by leukocytes during phagocytosis.
 Product Categories/Family for SERPINA1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Serpin
NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
 NCBI GI #    50363217
 NCBI GeneID    5265
 NCBI Accession #    NP_000286.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000295.4 [Other Products]
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 UniProt Primary Accession #    P01009 [Other Products]
 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 UniProt Related Accession #    P01009 [Other Products]
 Molecular Weight    34,755 Da
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 NCBI Official Full Name    alpha-1-antitrypsin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
 NCBI Official Symbol    SERPINA1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
[Similar Products]
 NCBI Protein Information    alpha-1-antitrypsin; alpha-1 protease inhibitor; alpha-1-antiproteinase; alpha-1-antitrypsin null; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin A1
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1Short peptide from AAT; SPAAT
 Protein Family    Alpha-1-antitrypsin
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI; SPAAT [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for SERPINA1    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA1    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; response to methanol; acute-phase response; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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 Research Articles on SERPINA1    1. Alpha-1 Antitrypsin is the most abundant serpin within the circulation and has been shown to increase in response to inflammation. [Review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPINA1 recombinant proteinDiseases associated with SERPINA1 recombinant protein
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >133 publications with SERPINA1 and Lung Diseases
 alpha 1-Antitrypsin Deficiency Antibodies  >130 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >121 publications with SERPINA1 and Liver Diseases
 Pulmonary Disease, Chronic Obstructive Antibodies  >53 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
 Inflammation Antibodies  >36 publications with SERPINA1 and Inflammation
 Pulmonary Emphysema Antibodies  >36 publications with SERPINA1 and Pulmonary Emphysema
 Liver Cirrhosis Antibodies  >29 publications with SERPINA1 and Liver Cirrhosis
 Carcinoma, Hepatocellular Antibodies  >21 publications with SERPINA1 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >18 publications with SERPINA1 and Adenocarcinoma
 Hepatitis Antibodies  >18 publications with SERPINA1 and Hepatitis
Organs/Tissues associated with SERPINA1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >109 publications with SERPINA1 and Liver
 Blood Antibodies  >104 publications with SERPINA1 and Blood
 Lung Antibodies  >72 publications with SERPINA1 and Lung
 Skin Antibodies  >14 publications with SERPINA1 and Skin
 Vascular Antibodies  >11 publications with SERPINA1 and Vascular
 Heart Antibodies  >11 publications with SERPINA1 and Heart
 Kidney Antibodies  >10 publications with SERPINA1 and Kidney
 Pancreas Antibodies  >10 publications with SERPINA1 and Pancreas
 Bone Antibodies  >9 publications with SERPINA1 and Bone
 Muscle Antibodies  >8 publications with SERPINA1 and Muscle
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