NP_038489.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-1A adrenergic receptor isoform 1
NCBI Official Synonym Full Names
adrenergic receptor, alpha 1a
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor
UniProt Protein Name
Alpha-1A adrenergic receptor
UniProt Synonym Protein Names
Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor
UniProt Synonym Gene Names
UniProt Entry Name
ADA1A_MOUSE
NCBI Summary for Adra1a
This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for Adra1a
ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: nuclear membrane; membrane; T-tubule; integral to membrane; plasma membrane; cytosol; nucleus; Z disc
Molecular Function: G-protein coupled receptor activity; signal transducer activity; adrenoceptor activity; protein heterodimerization activity; alpha1-adrenergic receptor activity
Biological Process: regulation of muscle contraction; response to hormone stimulus; positive regulation of systemic arterial blood pressure; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; signal transduction; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of action potential; positive regulation of smooth muscle contraction; cell growth; aging; response to drug; adult heart development; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of synaptic transmission, GABAergic; positive regulation of heart rate; micturition; organ growth; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; G-protein coupled receptor protein signaling pathway; negative regulation of Rho protein signal transduction; phospholipase C activation; regulation of vasoconstriction; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of heart rate by epinephrine-norepinephrine
Research Articles on Adra1a
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Pathways associated with Adra1a recombinant protein
Diseases associated with Adra1a recombinant protein
Organs/Tissues associated with Adra1a recombinant protein
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