P08716.1
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UniProt Primary Accession #
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NCBI Official Full Name
Alpha-hemolysin translocation ATP-binding protein HlyB
UniProt Protein Name
Alpha-hemolysin translocation ATP-binding protein HlyB
UniProt Entry Name
HLYBP_ECOLX
UniProt Comments for hlyB
Function: Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Subunit structure: Homodimer.
Subcellular location: Cell inner membrane; Multi-pass membrane protein
Probable.
Domain: In HlyB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Miscellaneous: The complex HlyBD-TolC (OMF) forms a single transport channel across the two membranes, allowing direct export of alpha-hemolysin. This channel is involved in type 1 secretion system.
Sequence similarities: Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.Contains 1 peptidase C39 domain.
Caution: Tyr-9 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus this protein is presumed to be without peptidase activity.
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Products associated with hlyB recombinant protein
Pathways associated with hlyB recombinant protein
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