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Snca recombinant protein :: Alpha-synuclein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958569
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $700 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $850 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $945 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,060 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,070 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,090 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,555 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,610 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,665 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,080 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-synuclein (Snca), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Alpha-synuclein

 Product Gene Name   

Snca recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS958569 COA    COA PDF
 Sequence Positions    1-140aa; Full Length
 Sequence    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP SSEAYEMPSE EGYQDYEPEA
 3D Structure    ModBase 3D Structure for P37377
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Snca recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Snca recombinant protein

   May be involved in the regulation of dopamine release and transport.
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 SDS-Page of Snca recombinant protein    Snca recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Snca. It may not necessarily be applicable to this product.
 NCBI GI #    9507125
 NCBI GeneID    29219
 NCBI Accession #    NP_062042.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019169.2 [Other Products]
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 UniProt Primary Accession #    P37377 [Other Products]
 UniProt Secondary Accession #    P37378; Q53YM9 [Other Products]
 UniProt Related Accession #    P37377 [Other Products]
 Molecular Weight    41.9kD
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 NCBI Official Full Name    alpha-synuclein
 NCBI Official Synonym Full Names    synuclein alpha
 NCBI Official Symbol    Snca [Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 Protein Family    Alpha-synuclein
 UniProt Gene Name    Snca [Similar Products]
 UniProt Entry Name    SYUA_RAT
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 NCBI Summary for Snca    may play a role in regulation of synaptic vesicle biogenesis and organization; may be involved in neurotransmission [RGD, Feb 2006]
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 UniProt Comments for Snca    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cytoplasm; cytoplasmic vesicle membrane; cytoskeleton; cytosol; extracellular space; fibril; Golgi apparatus; growth cone; inclusion body; intracellular membrane-bound organelle; membrane; mitochondrion; nerve terminal; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; ribosome; rough endoplasmic reticulum; synapse; synaptic vesicle; terminal button

Molecular Function: alpha-tubulin binding; arachidonic acid binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; dynein binding; enzyme binding; fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; zinc ion binding

Biological Process: adult locomotory behavior; aging; behavioral response to cocaine; calcium ion homeostasis; caspase activation; dopamine biosynthetic process; dopamine metabolic process; fatty acid metabolic process; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of norepinephrine uptake; negative regulation of protein amino acid phosphorylation; negative regulation of serotonin uptake; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of endocytosis; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of excitatory postsynaptic membrane potential; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; regulation of neuron apoptosis; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; response to cocaine; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization and biogenesis; synaptic transmission; synaptic transmission, dopaminergic; synaptic vesicle endocytosis; synaptic vesicle transport
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Product References and Citations for Snca recombinant protein

   The rat brain synucleins; family of proteins transiently associated with neuronal membrane.Maroteaux L., Scheller R.H.Brain Res. Mol. Brain Res. 11:335-343(1991) Synuclein a neuron-specific protein localized to the nucleus and presynaptic nerve terminal.Maroteaux L., Campanelli J.T., Scheller R.H.J. Neurosci. 8:2804-2815(1988) Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.Kholodilov N.G., Neystat M., Oo T.F., Lo S.E., Larsen K.E., Sulzer D., Burke R.E.J. Neurochem. 73:2586-2599(1999) Alpha-synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and - nonpreferring rats.Liang T., Spence J., Liu L., Strother W.N., Chang H.W., Ellison J.A., Lumeng L., Li T.K., Foroud T., Carr L.G.Proc. Natl. Acad. Sci. U.S.A. 100:4690-4695(2003) Lubec G., Chen W.-Q.Submitted (APR-2007) to UniProtKB The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Liu Y., Fallon L., Lashuel H.A., Liu Z., Lansbury P.T. Jr.Cell 111:209-218(2002)
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 Research Articles on Snca    1. Mitochondrial impairment disturbs the autophagic flux and leads to the accumulation of exogenously applied alpha-synuclein
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Snca recombinant proteinDiseases associated with Snca recombinant protein
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1264 publications with Snca and Nervous System Diseases
 Brain Diseases Antibodies  >1239 publications with Snca and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1221 publications with Snca and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1098 publications with Snca and Movement Disorders
 Parkinsonian Disorders Antibodies  >1014 publications with Snca and Parkinsonian Disorders
 Parkinson Disease Antibodies  >957 publications with Snca and Parkinson Disease
 Lewy Body Disease Antibodies  >300 publications with Snca and Lewy Body Disease
 Nerve Degeneration Antibodies  >174 publications with Snca and Nerve Degeneration
 Disease Models, Animal Antibodies  >171 publications with Snca and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >58 publications with Snca and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
Organs/Tissues associated with Snca recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >881 publications with Snca and Brain
 Heart Antibodies  >12 publications with Snca and Heart
 Eye Antibodies  >12 publications with Snca and Eye
 Liver Antibodies  >10 publications with Snca and Liver
 Dorsal Root Ganglion Antibodies  >6 publications with Snca and Dorsal Root Ganglion
 Prostate Antibodies  >2 publications with Snca and Prostate
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