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AMELX recombinant protein :: Amelogenin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145905 AMELX recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amelogenin (AMELX), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Amelogenin, X-Linked

 Product Synonym Names    AMELX Human; Amelogenin, X-Linked Human Recombinant; Amelogenin X isoform; AMELX; AMG; AMGX; AI1E; AIH1; ALGN; AMGL
 Product Gene Name   

AMELX recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGS PLPPHP GHPGYINFSY EVLTPLKWYQ SIRPPYPSYG YEPMGGWLHH QIIPVLSQQH PPTHTLQPHH HIPVVPAQQP VIPQQPMMPV PGQHSMTPIQ HHQPNLPPPA QQPYQPQPVQ PQPHQPMQPQ PPVHPMQPLP PQPPLPPMFP MQPLPPMLPD LTLEAWPSTD KTKREEVD.
 OMIM    300391
 3D Structure    ModBase 3D Structure for Q99217
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    AMELX protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.5), 0.2M NaCl, 30% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of AMELX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AMELX recombinant protein

   Description: AMELX Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (17-191 a.a) and having a molecular mass of 22kDa.AMELX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Amelogenin, X-Linked (AMELX) belongs to the amelogenin family of extracellular matrix proteins. Amelogenins have a role biomineralization during tooth enamel development. AMELX gene mutations cause X-linked amelogenesis imperfecta. AMELX regulates the formation of crystallites during the secretory stage of tooth enamel development. AMELX is transiently but amply expressed by ameloblasts during tooth development. Amelogenin is the principal protein in developing dental enamel.
 Product Categories/Family for AMELX recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for AMELX. It may not necessarily be applicable to this product.
 NCBI GI #    4502071
 NCBI GeneID    265
 NCBI Accession #    NP_001133.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142.2 [Other Products]
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 UniProt Primary Accession #    Q99217 [Other Products]
 UniProt Secondary Accession #    Q96NW6; Q9UCA7 [Other Products]
 UniProt Related Accession #    Q99217 [Other Products]
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 NCBI Official Full Name    amelogenin, X isoform isoform 1
 NCBI Official Synonym Full Names    amelogenin, X-linked
 NCBI Official Symbol    AMELX [Similar Products]
 NCBI Official Synonym Symbols   
AMG; AI1E; AIH1; ALGN; AMGL; AMGX
[Similar Products]
 NCBI Protein Information    amelogenin, X isoform; amelogenesis imperfecta 1; amelogenin (X chromosome, amelogenesis imperfecta 1); amelogenin (amelogenesis imperfecta 1, X-linked)
 UniProt Protein Name    Amelogenin, X isoform
 Protein Family    Amelogenin
 UniProt Gene Name    AMELX [Similar Products]
 UniProt Synonym Gene Names    AMG; AMGX [Similar Products]
 UniProt Entry Name    AMELX_HUMAN
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 NCBI Summary for AMELX    This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AMELX    AMELX: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Defects in AMELX are the cause of amelogenesis imperfecta type 1E (AI1E). A X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. Belongs to the amelogenin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xp22.31-p22.1

Cellular Component: proteinaceous extracellular matrix; cell surface

Molecular Function: identical protein binding; protein binding; growth factor activity; hydroxyapatite binding; structural constituent of tooth enamel

Biological Process: osteoblast differentiation; cell proliferation; ion homeostasis; biomineral formation; positive regulation of collagen biosynthetic process; chondrocyte differentiation; epithelial to mesenchymal transition; signal transduction; cell adhesion; odontogenesis of dentine-containing teeth

Disease: Amelogenesis Imperfecta, Type Ie
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 Research Articles on AMELX    1. silent mutation in exon 4 of AMELX gene. generating and characterizing transgenic animal model, alteration of the ratio and quantity of the developmentally conserved alternative splicing repertoire of AMELX caused defects in enamel matrix mineralization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AMELX recombinant proteinDiseases associated with AMELX recombinant protein
 Reference Product  PubMed Publications
 ENAM recombinant protein  >34 publications with AMELX and ENAM
 MMP20 recombinant protein  >33 publications with AMELX and MMP20
 BGN recombinant protein  >4 publications with AMELX and BGN
 TUFT1 recombinant protein  >3 publications with AMELX and TUFT1
 AMTN recombinant protein  >3 publications with AMELX and AMTN
 DMP1 recombinant protein  >3 publications with AMELX and DMP1
 LAMP1 recombinant protein  >2 publications with AMELX and LAMP1
 KRT5 recombinant protein  >1 publications with AMELX and KRT5
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with AMELX and Carcinoma
 Weight Loss Antibodies  >2 publications with AMELX and Weight Loss
 Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 1 Antibodies  >2 publications with AMELX and Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 1
 Renal Insufficiency Antibodies  >1 publications with AMELX and Renal Insufficiency
 Anemia Antibodies  >1 publications with AMELX and Anemia
 Brain Diseases Antibodies  >1 publications with AMELX and Brain Diseases
 Hemorrhage Antibodies  >1 publications with AMELX and Hemorrhage
 Inflammation Antibodies  >1 publications with AMELX and Inflammation
 Necrosis Antibodies  >1 publications with AMELX and Necrosis
 Hyperplasia Antibodies  >1 publications with AMELX and Hyperplasia
Organs/Tissues associated with AMELX recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >5 publications with AMELX and Connective Tissue
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