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APP recombinant protein :: Amyloid beta A4 protein (APP) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1454485 APP recombinant protein
Unit / Price
0.05 mg (Baculovirus)  /  $1,890 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $2,050 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $2,245 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,360 +2 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $2,525 +3 FREE 8GB USB
1 mg (E-Coli)  /  $2,535 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,965 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $3,155 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $3,730 +4 FREE 8GB USB
1 mg (Baculovirus)  /  $4,660 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amyloid beta A4 protein (APP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Pan troglodytes Amyloid beta A4 protein (APP), partial

 Product Gene Name   

APP recombinant protein

[Similar Products]
 Product Synonym Gene Name    APP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    18-663aa; Partial, provide the fragment of the Soluble APP-beta chain
 Sequence    LEVPTDGNAG LLAEPQIAMF CGRLNMHMNV QNGKWDSDPS GTKTCIDTKE GILQYCQEVY PELQITNVVE ANQPVTIQNW CKRGRKQCKT HPHFVIPYRC LVGEFVSDAL LVPDKCKFLH QERMDVCETH LHWHTVAKET CSEKSTNLHD YGMLLPCGID KFRGVEFVCC PLAEESDNVD SADAEEDDSD VWWGGADTDY ADGSEDKVVE VAEEEEVAEV EEEEADDDED DEDGDEVEEE AEEPYEEATE RTTSIATTTT TTTESVEEVV REVCSEQAET GPCRAMISRW YFDVTEGKCA PFFYGGCGGN RNNFDTEEYC MAVCGSVMSQ SLLKTTQEPL ARDPVKLPTT AASTPDAVDK YLETPGDENE HAHFQKAKER LEAKHRERMS QVMREWEEAE RQAKNLPKAD KKAVIQHFQE KVESLEQEAA NERQQLVETH MARVEAMLND RRRLALENYI TALQAVPPRP RHVFNMLKKY VRAEQKDRQH TLKHFEHVRM VDPKKAAQIR SQVMTHLRVI YERMNQSLSL LYNVPAVAEE IQDEVDELLQ KEQNYSDDVL ANMISEPRIS YGNDALMPSL TETKTTVELL PVNGEFSLDD LQPWHSFGAD SVPANTENEV EPVDARPAAD RGLTTRPGSG LTNIKT
 3D Structure    ModBase 3D Structure for Q5IS80
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Pan troglodytes (Chimpanzee)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of APP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for APP. It may not necessarily be applicable to this product.
 NCBI GI #    61316399
 NCBI GeneID    473931
 NCBI Accession #    NP_001013036.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001013018.1 [Other Products]
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 UniProt Primary Accession #    Q5IS80 [Other Products]
 UniProt Related Accession #    Q5IS80 [Other Products]
 Molecular Weight    86,971 Da
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 NCBI Official Full Name    amyloid-beta A4 protein
 NCBI Official Synonym Full Names    amyloid beta precursor protein
 NCBI Official Symbol    APP [Similar Products]
 NCBI Protein Information    amyloid-beta A4 protein; amyloid beta A4 protein
 UniProt Protein Name    Amyloid-beta A4 protein
 UniProt Synonym Protein Names   
ABPP; APP
 Protein Family    Amyloid beta A4 protein
 UniProt Gene Name    APP [Similar Products]
 UniProt Synonym Gene Names    APP; S-APP-alpha; S-APP-beta; Beta-CTF; Abeta42; Abeta40; Alpha-CTF [Similar Products]
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 UniProt Comments for APP    Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (). Inhibits G(o) alpha ATPase activity (). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (). May be involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation (). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 ().
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APP recombinant proteinPathways associated with APP recombinant protein
 Reference Product  PubMed Publications
 BACE1 recombinant protein  >1122 publications with APP and BACE1
 PSEN1 recombinant protein  >637 publications with APP and PSEN1
 APOE recombinant protein  >478 publications with APP and APOE
 PSEN2 recombinant protein  >274 publications with APP and PSEN2
 APBB1 recombinant protein  >109 publications with APP and APBB1
 IDE recombinant protein  >47 publications with APP and IDE
 TGFB1 recombinant protein  >21 publications with APP and TGFB1
 ITM2B recombinant protein  >20 publications with APP and ITM2B
 GAPDH recombinant protein  >15 publications with APP and GAPDH
 NAE1 recombinant protein  >2 publications with APP and NAE1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
Diseases associated with APP recombinant proteinOrgans/Tissues associated with APP recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5242 publications with APP and Nervous System Diseases
 Brain Diseases Antibodies  >4996 publications with APP and Brain Diseases
 Alzheimer Disease Antibodies  >4934 publications with APP and Alzheimer Disease
 Dementia Antibodies  >4616 publications with APP and Dementia
 Neurodegenerative Diseases Antibodies  >4600 publications with APP and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >1636 publications with APP and Disease Models, Animal
 Plaque, Amyloid Antibodies  >1155 publications with APP and Plaque, Amyloid
 Inflammation Antibodies  >587 publications with APP and Inflammation
 Memory Disorders Antibodies  >332 publications with APP and Memory Disorders
 Necrosis Antibodies  >299 publications with APP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Frontal Lobe Antibodies  >90 publications with APP and Brain Frontal Lobe
 Cerebellum Cortex Antibodies  >80 publications with APP and Cerebellum Cortex
 Skin, Epidermal Tissue Antibodies  >14 publications with APP and Skin, Epidermal Tissue
 Brain Occipital Lobe Antibodies  >12 publications with APP and Brain Occipital Lobe
 Brain, Presumably Cortex Antibodies  >5 publications with APP and Brain, Presumably Cortex
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