NP_999537.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,961 Da
NCBI Official Full Name
amyloid beta A4 protein
NCBI Protein Information
amyloid beta A4 protein
UniProt Protein Name
Amyloid beta A4 protein
UniProt Synonym Protein Names
ABPP; APP
UniProt Synonym Gene Names
UniProt Entry Name
A4_PIG
UniProt Comments for APP
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (). Inhibits G(o) alpha ATPase activity (). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (). May be involved in copper homeostasis/oxidative stress through copper ion reduction (). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation (). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 ().
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Products associated with APP recombinant protein
Pathways associated with APP recombinant protein
Diseases associated with APP recombinant protein
Organs/Tissues associated with APP recombinant protein
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