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ANGPT1 recombinant protein :: Angiopoietin 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS537938 ANGPT1 recombinant protein
Unit / Price
0.005 mg  /  $255 +1 FREE 8GB USB
0.02 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiopoietin 1 (ANGPT1), Recombinant Protein

 Also Known As   

Angiopoietin 1 protein

 Product Synonym Names    Angiopoietin 1; ANG1 protein; AGP 1 protein; ANGPT1 protein; ANGPT 1 protein; ANG 1 protein; Angiopoietin -1 protein; AGPT protein; AGP1 protein; Angiopoietin -1; KIAA0003 protein; Angiopoietin 1 protein; Angiopoietin1 protein
 Product Gene Name   

ANGPT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601667
 3D Structure    ModBase 3D Structure for Q15389
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied as a lyophilized powder. Reconstitute in PBS or water to a concentration not lower than 100 ug/ml, pH 7.4.
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 Protein Type    Recombinant
 Biological Significance    The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase.
 Expression System    HeLa Cells
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ANGPT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANGPT1 recombinant protein

   Purified recombinant Human Angiopoietin 1 protein
 Product Categories/Family for ANGPT1 recombinant protein    Differentiation & Development
 Applications Tested/Suitable for ANGPT1 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ANGPT1. It may not necessarily be applicable to this product.
 NCBI GI #    20532340
 NCBI GeneID    284
 NCBI Accession #    NP_001137.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001146.3 [Other Products]
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 UniProt Primary Accession #    Q15389 [Other Products]
 UniProt Secondary Accession #    Q5HYA0 [Other Products]
 UniProt Related Accession #    Q15389 [Other Products]
 Molecular Weight    60-70 kDa [Similar Products]
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 NCBI Official Full Name    angiopoietin-1 isoform 1
 NCBI Official Synonym Full Names    angiopoietin 1
 NCBI Official Symbol    ANGPT1 [Similar Products]
 NCBI Official Synonym Symbols   
AGP1; AGPT; ANG1
[Similar Products]
 NCBI Protein Information    angiopoietin-1
 UniProt Protein Name    Angiopoietin-1
 Protein Family    Angiopoietin
 UniProt Gene Name    ANGPT1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0003; ANG-1 [Similar Products]
 UniProt Entry Name    ANGP1_HUMAN
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 NCBI Summary for ANGPT1    Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
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 UniProt Comments for ANGPT1    ANGPT1: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: extracellular space; microvillus; plasma membrane; extracellular region; lipid raft

Molecular Function: receptor tyrosine kinase binding

Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of cell adhesion; positive regulation of receptor internalization; negative regulation of protein import into nucleus; negative regulation of cell adhesion; negative regulation of protein amino acid phosphorylation; positive chemotaxis; hemopoiesis; negative regulation of neuron apoptosis; cell differentiation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of endothelial cell proliferation; Tie receptor signaling pathway; in utero embryonic development; positive regulation of blood vessel endothelial cell migration; positive regulation of peptidyl-serine phosphorylation; cell-substrate adhesion; negative regulation of cytokine secretion during immune response; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; heparin biosynthetic process; positive regulation of protein ubiquitination; regulation of protein binding; negative regulation of vascular permeability; regulation of tumor necrosis factor production; regulation of satellite cell proliferation; sprouting angiogenesis; blood coagulation; leukocyte migration; negative regulation of apoptosis
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 Research Articles on ANGPT1    1. These experiments suggested that some human herpesvirus 8-infected PEL cell line-specific DNA-binding factors, such as OCT-1, should be involved in the upregulation of ANGPT-1 in a sequence-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANGPT1 recombinant proteinPathways associated with ANGPT1 recombinant protein
 Reference Product  PubMed Publications
 ANGPT2 recombinant protein  >333 publications with ANGPT1 and ANGPT2
 VEGFA recombinant protein  >89 publications with ANGPT1 and VEGFA
 TEK recombinant protein  >41 publications with ANGPT1 and TEK
 KDR recombinant protein  >12 publications with ANGPT1 and KDR
 FLT1 recombinant protein  >10 publications with ANGPT1 and FLT1
 MMP2 recombinant protein  >6 publications with ANGPT1 and MMP2
 ELF2 recombinant protein  >1 publications with ANGPT1 and ELF2
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
Diseases associated with ANGPT1 recombinant proteinOrgans/Tissues associated with ANGPT1 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >70 publications with ANGPT1 and Disease Models, Animal
 Inflammation Antibodies  >63 publications with ANGPT1 and Inflammation
 Nervous System Diseases Antibodies  >42 publications with ANGPT1 and Nervous System Diseases
 Heart Diseases Antibodies  >35 publications with ANGPT1 and Heart Diseases
 Lung Diseases Antibodies  >33 publications with ANGPT1 and Lung Diseases
 Immune System Diseases Antibodies  >28 publications with ANGPT1 and Immune System Diseases
 Edema Antibodies  >22 publications with ANGPT1 and Edema
 Kidney Diseases Antibodies  >22 publications with ANGPT1 and Kidney Diseases
 Necrosis Antibodies  >22 publications with ANGPT1 and Necrosis
 Neoplasms, Experimental Antibodies  >21 publications with ANGPT1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >474 publications with ANGPT1 and Vascular
 Blood Antibodies  >351 publications with ANGPT1 and Blood
 Muscle Antibodies  >96 publications with ANGPT1 and Muscle
 Brain Antibodies  >61 publications with ANGPT1 and Brain
 Heart Antibodies  >60 publications with ANGPT1 and Heart
 Embryonic Tissue Antibodies  >56 publications with ANGPT1 and Embryonic Tissue
 Bone Antibodies  >52 publications with ANGPT1 and Bone
 Lung Antibodies  >44 publications with ANGPT1 and Lung
 Liver Antibodies  >39 publications with ANGPT1 and Liver
 Bone Marrow Antibodies  >38 publications with ANGPT1 and Bone Marrow
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