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ANGPT2 recombinant protein :: Angiopoietin 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS537250 ANGPT2 recombinant protein
Unit / Price
0.005 mg  /  $255 +1 FREE 8GB USB
0.02 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiopoietin 2 (ANGPT2), Recombinant Protein

★Popular Item★
 Also Known As   

Angiopoietin 2 protein

 Product Synonym Names    Angiopoietin-2 protein; ANGPT 2 protein; Angiopoietin 2; Angiopoietin-2; Angiopoietin2 protein; ANGPT2 protein; Angiopoietin 2 protein; KIAA0003 protein; ANG 2 protein; ANG2 protein; AGP 2 protein; AGPT protein; AGP2 protein
 Product Gene Name   

ANGPT2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601922
 3D Structure    ModBase 3D Structure for O15123
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 Purity/Purification    > 95% by SDS-PAGE and HPLC
 Form/Format    Lyophilized from 10mM sodium phosphate buffer, pH8.0. Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not Vortex!
 Concentration    20 ug lyophilized (lot specific)
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 Source    CHO cells
 Protein Type    Recombinant
 Biological Significance    The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase.
 Expression System    Sf-9 insect cells
 Contaminants    Endotoxin: <0.1ng/ug
 Biohazard    Use appropriate laboratory precautions when handling this product.
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 Preparation and Storage    Ships ambient or refrigerated; after receipt, store at 4 degree C short term, -20 degree C long term. Avoid repeated freeze/thaw cycles. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (e.g. 0.1% BSA) and store in working aliquots at -20 degree C.
 Other Notes    Small volumes of ANGPT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANGPT2 recombinant protein

   Purified recombinant Human Angiopoietin 2 protein
 Product Categories/Family for ANGPT2 recombinant protein    Differentiation & Development
 Applications Tested/Suitable for ANGPT2 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ANGPT2. It may not necessarily be applicable to this product.
 NCBI GI #    116496775
 NCBI GeneID    285
 NCBI Accession #    AAI26201.1 [Other Products]
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 UniProt Primary Accession #    O15123 [Other Products]
 UniProt Secondary Accession #    Q9NRR7; Q9P2Y7; A0AV38; A8K205; B7ZLM7 [Other Products]
 UniProt Related Accession #    O15123 [Other Products]
 Molecular Weight    66 kDa [Similar Products]
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 NCBI Official Full Name    Angiopoietin 2
 NCBI Official Synonym Full Names    angiopoietin 2
 NCBI Official Symbol    ANGPT2 [Similar Products]
 NCBI Official Synonym Symbols   
ANG2; AGPT2
[Similar Products]
 NCBI Protein Information    angiopoietin-2
 UniProt Protein Name    Angiopoietin-2
 Protein Family    Angiopoietin
 UniProt Gene Name    ANGPT2 [Similar Products]
 UniProt Synonym Gene Names    ANG-2 [Similar Products]
 UniProt Entry Name    ANGP2_HUMAN
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 NCBI Summary for ANGPT2    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANGPT2    ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; cell projection; extracellular region; plasma membrane; nucleus

Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding

Biological Process: organ regeneration; Tie receptor signaling pathway; maternal process involved in pregnancy; negative regulation of blood vessel endothelial cell migration; signal transduction; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; response to radiation; positive regulation of angiogenesis; negative regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration
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 Research Articles on ANGPT2    1. the positive correlation between Ang-2 and Tie-2 levels in metastatic subjects, implies that cases with a Tie-2 level above the upper limits, together with higher level of Ang-2 seem to be highly predictive of metastases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANGPT2 recombinant proteinPathways associated with ANGPT2 recombinant protein
 Reference Product  PubMed Publications
 ANGPT1 recombinant protein  >333 publications with ANGPT2 and ANGPT1
 VEGFA recombinant protein  >153 publications with ANGPT2 and VEGFA
 FGF2 recombinant protein  >63 publications with ANGPT2 and FGF2
 TEK recombinant protein  >49 publications with ANGPT2 and TEK
 TIE1 recombinant protein  >36 publications with ANGPT2 and TIE1
 KDR recombinant protein  >34 publications with ANGPT2 and KDR
 FLT1 recombinant protein  >24 publications with ANGPT2 and FLT1
 FOXO1 recombinant protein  >8 publications with ANGPT2 and FOXO1
 ETS1 recombinant protein  >6 publications with ANGPT2 and ETS1
 FLT4 recombinant protein  >2 publications with ANGPT2 and FLT4
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram
Diseases associated with ANGPT2 recombinant proteinOrgans/Tissues associated with ANGPT2 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >285 publications with ANGPT2 and Cardiovascular Diseases
 Inflammation Antibodies  >251 publications with ANGPT2 and Inflammation
 Disease Models, Animal Antibodies  >174 publications with ANGPT2 and Disease Models, Animal
 Necrosis Antibodies  >122 publications with ANGPT2 and Necrosis
 Heart Diseases Antibodies  >84 publications with ANGPT2 and Heart Diseases
 Liver Diseases Antibodies  >84 publications with ANGPT2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >82 publications with ANGPT2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >80 publications with ANGPT2 and Kidney Diseases
 Liver Neoplasms Antibodies  >77 publications with ANGPT2 and Liver Neoplasms
 Hypertension Antibodies  >74 publications with ANGPT2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1388 publications with ANGPT2 and Vascular
 Muscle Antibodies  >186 publications with ANGPT2 and Muscle
 Lung Antibodies  >150 publications with ANGPT2 and Lung
 Embryonic Tissue Antibodies  >149 publications with ANGPT2 and Embryonic Tissue
 Brain Antibodies  >144 publications with ANGPT2 and Brain
 Liver Antibodies  >127 publications with ANGPT2 and Liver
 Kidney Antibodies  >114 publications with ANGPT2 and Kidney
 Eye Antibodies  >100 publications with ANGPT2 and Eye
 Placenta Antibodies  >75 publications with ANGPT2 and Placenta
 Bone Marrow Antibodies  >69 publications with ANGPT2 and Bone Marrow
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