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ANGPTL3 recombinant protein :: Angiopoietin-like Protein 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142125 ANGPTL3 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,230 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiopoietin-like Protein 3 (ANGPTL3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Angiopoietin-like Protein 3

 Product Synonym Names    ANGPTL3 Human; Angiopoietin Like Protein 3 Human Recombinant; Angiopoietin 5; ANGPT5; ANGPTL3; Angiopoietin Like Protein 3
 Product Gene Name   

ANGPTL3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604774
 3D Structure    ModBase 3D Structure for Q9Y5C1
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 Host    E Coli
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 Purity/Purification    Angiopoietin 5 purity is greater than 95% as determined by SDS-PAGE.
 Form/Format    ANGPTL3 Human filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
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 Solubility    Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet of ANGPTL3 Human dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of Angiopoietin 5 is limited.
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 Preparation and Storage    Store lyophilized ANGPTL3 Human at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Angiopoietin 5 can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of ANGPTL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANGPTL3 recombinant protein

   Description: The ANGPTL3 Human Recombinant is produced with N-terminal fusion of His-Tag. The Angiopoietin-like protein 3 His Tagged Fusion Protein is 26kDa containing 207 amino acid residues of the ANGPTL3 Human and 16 additional amino acid residues His-Tag (underlined).

Introduction: ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states (feeding/fasting) the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase (LPL) as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins (vascular endothelial growth factors). Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain (fragment 17-207) and not the C-terminal fibrinogen-like domain (fragment 207-460) increased the plasma triglyceride levels in mice.
 Product Categories/Family for ANGPTL3 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Angiopoietin
NCBI/Uniprot data below describe general gene information for ANGPTL3. It may not necessarily be applicable to this product.
 NCBI GI #    7656888
 NCBI GeneID    27329
 NCBI Accession #    NP_055310.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014495.3 [Other Products]
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 UniProt Primary Accession #    Q9Y5C1 [Other Products]
 UniProt Secondary Accession #    A0JLS0; B1ALJ0; B2RCW1 [Other Products]
 UniProt Related Accession #    Q9Y5C1 [Other Products]
 Molecular Weight    53,637 Da
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 NCBI Official Full Name    angiopoietin-related protein 3 preproprotein
 NCBI Official Synonym Full Names    angiopoietin-like 3
 NCBI Official Symbol    ANGPTL3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    angiopoietin-related protein 3; angiopoietin 5
 UniProt Protein Name    Angiopoietin-related protein 3
 UniProt Synonym Protein Names   
Angiopoietin-5; ANG-5; Angiopoietin-like protein 3
 Protein Family    Angiopoietin-related protein
 UniProt Gene Name    ANGPTL3 [Similar Products]
 UniProt Synonym Gene Names    ANGPT5; ANG-5 [Similar Products]
 UniProt Entry Name    ANGL3_HUMAN
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 NCBI Summary for ANGPTL3    This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
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 UniProt Comments for ANGPTL3    ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.

Protein type: Secreted, signal peptide; Inhibitor; Motility/polarity/chemotaxis; Secreted; Cell adhesion

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: extracellular space; cell surface

Molecular Function: integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity

Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; glycerol metabolic process; phospholipid catabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; positive regulation of angiogenesis; sequestering of lipid; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; phospholipid homeostasis; positive regulation of cell migration

Disease: Hypobetalipoproteinemia, Familial, 2
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 Research Articles on ANGPTL3    1. HCV core represses ANGPTL-3 expression through loss of HNF-1alpha binding activity and blockage of LXR/RXR transactivation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANGPTL3 recombinant proteinPathways associated with ANGPTL3 recombinant protein
 Reference Product  PubMed Publications
 LPL recombinant protein  >39 publications with ANGPTL3 and LPL
 APOA5 recombinant protein  >10 publications with ANGPTL3 and APOA5
 GPIHBP1 recombinant protein  >6 publications with ANGPTL3 and GPIHBP1
 TIE1 recombinant protein  >3 publications with ANGPTL3 and TIE1
 Products by Pathway  Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
Diseases associated with ANGPTL3 recombinant proteinOrgans/Tissues associated with ANGPTL3 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >24 publications with ANGPTL3 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >21 publications with ANGPTL3 and Atherosclerosis
 Fatty Liver Antibodies  >20 publications with ANGPTL3 and Fatty Liver
 Liver Diseases Antibodies  >13 publications with ANGPTL3 and Liver Diseases
 Disease Models, Animal Antibodies  >6 publications with ANGPTL3 and Disease Models, Animal
 Liver Neoplasms Antibodies  >4 publications with ANGPTL3 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with ANGPTL3 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with ANGPTL3 and Kidney Diseases
 Proteinuria Antibodies  >4 publications with ANGPTL3 and Proteinuria
 Inflammation Antibodies  >3 publications with ANGPTL3 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >64 publications with ANGPTL3 and Liver
 Muscle Antibodies  >8 publications with ANGPTL3 and Muscle
 Kidney Antibodies  >8 publications with ANGPTL3 and Kidney
 Brain Antibodies  >4 publications with ANGPTL3 and Brain
 Lung Antibodies  >3 publications with ANGPTL3 and Lung
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