NP_001039508.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
45,553 Da
NCBI Official Full Name
angiopoietin-related protein 4
NCBI Official Synonym Full Names
angiopoietin like 4
NCBI Protein Information
angiopoietin-related protein 4
UniProt Protein Name
Angiopoietin-related protein 4
UniProt Synonym Protein Names
Angiopoietin-like protein 4
UniProt Comments for ANGPTL4
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation ().
Research Articles on ANGPTL4
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Products associated with ANGPTL4 recombinant protein
Pathways associated with ANGPTL4 recombinant protein
Diseases associated with ANGPTL4 recombinant protein
Organs/Tissues associated with ANGPTL4 recombinant protein
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