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ANX1 recombinant protein :: Annexin A1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS964966 (PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $295 +1 FREE 8GB USB
0.5 mg  /  $580 +1 FREE 8GB USB
1 mg  /  $855 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Annexin A1 (ANX1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Annexin A1

 Product Synonym Names    Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory proteinp35
 Product Gene Name   

ANX1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    LPC1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS964966 COA    COA PDF
 Sequence Positions    5-346aa; Partial
 OMIM    151690
 3D Structure    ModBase 3D Structure for P04083
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ANX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANX1 recombinant protein

   Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It ses to bind from two to four calcium ions with high affinity.
 Product Categories/Family for ANX1 recombinant protein    Signal Transduction
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 SDS-PAGE of ANX1 recombinant protein    ANX1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ANX1. It may not necessarily be applicable to this product.
 NCBI GI #    4502101
 NCBI GeneID    301
 NCBI Accession #    NP_000691.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000700.2 [Other Products]
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 UniProt Primary Accession #    P04083 [Other Products]
 UniProt Related Accession #    P04083 [Other Products]
 Molecular Weight    42.4kD
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 NCBI Official Full Name    annexin A1
 NCBI Official Synonym Full Names    annexin A1
 NCBI Official Symbol    ANXA1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    annexin A1
 UniProt Protein Name    Annexin A1
 UniProt Synonym Protein Names   
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I
 Protein Family    Annexin
 UniProt Gene Name    ANXA1 [Similar Products]
 UniProt Synonym Gene Names    ANX1; LPC1 [Similar Products]
 UniProt Entry Name    ANXA1_HUMAN
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 NCBI Summary for ANX1    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ANX1    ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cornified envelope; cytoplasm; cytoplasmic vesicle membrane; early endosome membrane; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; extrinsic to membrane; focal adhesion; lateral plasma membrane; mast cell granule; mitochondrial membrane; nucleoplasm; nucleus; phagocytic cup; plasma membrane; protein complex; sarcolemma; vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; double-stranded DNA-dependent ATPase activity; helicase activity; phospholipase A2 inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; protein homodimerization activity; receptor binding; single-stranded DNA binding; single-stranded RNA binding; structural molecule activity

Biological Process: actin cytoskeleton reorganization; adaptive immune response; alpha-beta T cell differentiation; arachidonic acid secretion; cell surface receptor linked signal transduction; DNA duplex unwinding; DNA strand renaturation; endocrine pancreas development; G-protein signaling, coupled to cyclic nucleotide second messenger; gliogenesis; inflammatory response; innate immune response; insulin secretion; keratinocyte differentiation; monocyte chemotaxis; muscle contraction; myoblast migration involved in skeletal muscle regeneration; negative regulation of apoptosis; negative regulation of exocytosis; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of interleukin-2 production; positive regulation of neutrophil apoptosis; positive regulation of prostaglandin biosynthetic process; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; prostate gland development; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; response to drug; response to estradiol stimulus; response to peptide hormone stimulus; response to X-ray; signal transduction
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Product References and Citations for ANX1 recombinant protein

   Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.Wallner B.P., Mattaliano R.J., Hession C., Cate R.L., Tizard R., Sinclair L.K., Foeller C., Chow E.P., Browning J.L., Ramachandran K.L., Pepinsky R.B.Nature 320:77-81(1986) Correlation of gene and protein structure of rat and human lipocortin I.Kovacic R.T., Tizard R., Cate R.L., Frey A.Z., Wallner B.P.Biochemistry 30:9015-9021(1991) Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.Arcone R., Arpaia G., Ruoppolo M., Malorni A., Pucci P., Marino G., Ialenti A., di Rosa M., Ciliberto G.Eur. J. Biochem. 211:347-355(1993) Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.Varticovski L., Chahwala S.B., Whitman M., Cantley L., Schindler D., Chow E.P., Sinclair L.K., Pepinsky R.B.Biochemistry 27:3682-3690(1988) Characterization by tandem mass spectrometry of structural modifications in proteins.Biemann K., Scoble H.A.Science 237:992-998(1987) A dimeric form of lipocortin-1 in human placenta.Pepinsky R.B., Sinclair L.K., Chow E.P., O'Brine-Greco B.Biochem. J. 263:97-103(1989) Phosphorylation of annexin I by TRPM7 channel-kinase.Dorovkov M.V., Ryazanov A.G.J. Biol. Chem. 279:50643-50646(2004) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Crystal structure of human annexin I at 2.5-A resolution.Weng X., Luecke H., Song I.S., Kang D.S., Kim S.-H., Huber R.Protein Sci. 2:448-458(1993) NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit.Gao J., Li Y., Yan H.J. Biol. Chem. 274:2971-2977(1999)
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 Research Articles on ANX1    1. ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANX1 recombinant proteinPathways associated with ANX1 recombinant protein
 Reference Product  PubMed Publications
 FPR2 recombinant protein  >32 publications with ANX1 and FPR2
 FPR1 recombinant protein  >17 publications with ANX1 and FPR1
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 FPR3 recombinant protein  >4 publications with ANX1 and FPR3
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 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
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 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
Diseases associated with ANX1 recombinant proteinOrgans/Tissues associated with ANX1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >99 publications with ANX1 and Inflammation
 Carcinoma Antibodies  >65 publications with ANX1 and Carcinoma
 Disease Models, Animal Antibodies  >31 publications with ANX1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >25 publications with ANX1 and Neoplasm Metastasis
 Brain Diseases Antibodies  >22 publications with ANX1 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >19 publications with ANX1 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >14 publications with ANX1 and Neoplasm Invasiveness
 Cardiovascular Diseases Antibodies  >14 publications with ANX1 and Cardiovascular Diseases
 Necrosis Antibodies  >13 publications with ANX1 and Necrosis
 Stomach Diseases Antibodies  >12 publications with ANX1 and Stomach Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >113 publications with ANX1 and Blood
 Brain Antibodies  >36 publications with ANX1 and Brain
 Lung Antibodies  >29 publications with ANX1 and Lung
 Vascular Antibodies  >22 publications with ANX1 and Vascular
 Liver Antibodies  >20 publications with ANX1 and Liver
 Pituitary Gland Antibodies  >15 publications with ANX1 and Pituitary Gland
 Lymph Node Antibodies  >14 publications with ANX1 and Lymph Node
 Stomach Antibodies  >13 publications with ANX1 and Stomach
 Muscle Antibodies  >13 publications with ANX1 and Muscle
 Bone Antibodies  >12 publications with ANX1 and Bone
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