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ANXA2 recombinant protein :: Annexin A2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203687
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Annexin A2 (ANXA2), Recombinant Protein

 Also Known As   

Annexin A2, 1-339aa, Human, His tag, E Coli

 Product Synonym Names    ANX2; ANX2L4; CAL1H; LIP2; LPC2; LPC2D; P36; PAP-IV; ANXA2; annexin A2
 Product Gene Name   

ANXA2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMST VHEILCKLSL EGDHSTPPSA YGSVKAYTNF DAERDALNIE TAIKTKGVDE VTIVNILTNR SNAQRQDIAF AYQRRTKKEL ASALKSALSG HLETVILGLL KTPAQYDASE LKASMKGLGT DEDSLIEIIC SRTNQELQEI NRVYKEMYKT DLEKDIISDT SGDFRKLMVA LAKGRRAEDG SVIDYELIDQ DARDLYDAGV KRKGTDVPKW ISIMTERSVP HLQKVFDRYK SYSPYDMLES IRKEVKGDLE NAFLNLVQCI QNKPLYFADR LYDSMKGKGT RDKVLIRIMV SRSEVDMLKI RSEFKRKYGK SLYYYIQQDT KGDYQKALLY LCGGDD
 OMIM    D00017 mRNA
 3D Structure    ModBase 3D Structure for P07355
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol 0.1M NaCl
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of ANXA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANXA2 recombinant protein

   Annexin A2 belongs to a family of calcium-dependent membrane and phospholipid binding proteins. It plays a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Recombinant Annexin A2 protein was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for ANXA2 recombinant protein    Signal Transduction
 Applications Tested/Suitable for ANXA2 recombinant protein   

SDS-PAGE

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 SDS-Page of ANXA2 recombinant protein    ANXA2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for ANXA2. It may not necessarily be applicable to this product.
 NCBI GI #    50845386
 NCBI GeneID    302
 NCBI Accession #    NP_001002857 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002857.1 [Other Products]
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 UniProt Primary Accession #    P07355 [Other Products]
 UniProt Secondary Accession #    Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8 [Other Products]
 UniProt Related Accession #    P07355 [Other Products]
 Molecular Weight    42.8 kDa (376aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    annexin A2 isoform 2
 NCBI Official Synonym Full Names    annexin A2
 NCBI Official Symbol    ANXA2 [Similar Products]
 NCBI Official Synonym Symbols   
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
[Similar Products]
 NCBI Protein Information    annexin A2
 UniProt Protein Name    Annexin A2
 UniProt Synonym Protein Names   
Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
 Protein Family    Annexin
 UniProt Gene Name    ANXA2 [Similar Products]
 UniProt Synonym Gene Names    ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV [Similar Products]
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 NCBI Summary for ANXA2    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANXA2    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
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Product References and Citations for ANXA2 recombinant protein

   Emans N., et al. (1993) J. Cell Biol. 120 (6):1357-69; Zhao P,., et al. (2010) Cancer Sci. 101 (2):387-95.
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 Research Articles on ANXA2    1. results indicate that ANXA2 plays an important role to enhance the malignant behaviors of Hepatocellular carcinoma cells, and the enhancement is closely based on its remodeling to cell structures
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANXA2 recombinant proteinPathways associated with ANXA2 recombinant protein
 Reference Product  PubMed Publications
 S100A10 recombinant protein  >167 publications with ANXA2 and S100A10
 ANXA1 recombinant protein  >47 publications with ANXA2 and ANXA1
 LGALS1 recombinant protein  >16 publications with ANXA2 and LGALS1
 ANXA6 recombinant protein  >14 publications with ANXA2 and ANXA6
 PLG recombinant protein  >13 publications with ANXA2 and PLG
 AHNAK recombinant protein  >11 publications with ANXA2 and AHNAK
 PLAT recombinant protein  >9 publications with ANXA2 and PLAT
 DYSF recombinant protein  >4 publications with ANXA2 and DYSF
 CAV3 recombinant protein  >1 publications with ANXA2 and CAV3
 Products by Pathway  Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
Diseases associated with ANXA2 recombinant proteinOrgans/Tissues associated with ANXA2 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >126 publications with ANXA2 and Inflammation
 Cardiovascular Diseases Antibodies  >82 publications with ANXA2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >79 publications with ANXA2 and Disease Models, Animal
 Liver Diseases Antibodies  >74 publications with ANXA2 and Liver Diseases
 Neoplasm Invasiveness Antibodies  >65 publications with ANXA2 and Neoplasm Invasiveness
 Carcinoma, Hepatocellular Antibodies  >59 publications with ANXA2 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >55 publications with ANXA2 and Necrosis
 Liver Neoplasms Antibodies  >55 publications with ANXA2 and Liver Neoplasms
 Carcinoma, Squamous Cell Antibodies  >48 publications with ANXA2 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >47 publications with ANXA2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >307 publications with ANXA2 and Blood
 Vascular Antibodies  >195 publications with ANXA2 and Vascular
 Lung Antibodies  >138 publications with ANXA2 and Lung
 Brain Antibodies  >134 publications with ANXA2 and Brain
 Liver Antibodies  >123 publications with ANXA2 and Liver
 Muscle Antibodies  >95 publications with ANXA2 and Muscle
 Kidney Antibodies  >83 publications with ANXA2 and Kidney
 Bone Antibodies  >76 publications with ANXA2 and Bone
 Embryonic Tissue Antibodies  >54 publications with ANXA2 and Embryonic Tissue
 Intestine Antibodies  >44 publications with ANXA2 and Intestine
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