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ANX6 recombinant protein :: Annexin A6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717366
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Annexin A6 (ANX6), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Annexin A6 protein

 Product Synonym Names    67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70
 Product Gene Name   

ANX6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-245aa; Partial
 Sequence    AKPAQGAKYR GSIHDFPGFD PNQDAEALYT AMKGFGSDKE AILDIITSRS NRQRQEVCQS YKSLYGKDLI ADLKYELTGK FERLIVGLMR PPAYCDAKEI KDAISGIGTD EKCLIEILAS RTNEQMHQLV AAYKDAYERD LEADIIGDTS GHFQKMLVVL LQGTREEDDV VSEDLVQQDV QDLYEAGELK WGTDEAQFIY ILGNRSKQHL RLVFDEYLKT TGKPIEASIR GELSGDFEKL MLAV
 OMIM    114070
 3D Structure    ModBase 3D Structure for P08133
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ANX6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANX6 recombinant protein

   May associate with CD21. May regulate the release of Ca2+ from intracellular stores.
 Product Categories/Family for ANX6 recombinant protein    Signal Transduction
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 SDS-PAGE of ANX6 recombinant protein    ANX6 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ANX6. It may not necessarily be applicable to this product.
 NCBI GI #    71773329
 NCBI GeneID    309
 NCBI Accession #    NP_001146.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001155.4 [Other Products]
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 UniProt Primary Accession #    P08133 [Other Products]
 UniProt Secondary Accession #    Q6ZT79; B7Z8A7; D3DQH4; E9PGK1 [Other Products]
 UniProt Related Accession #    P08133 [Other Products]
 Molecular Weight    55.4kD
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 NCBI Official Full Name    annexin A6 isoform 1
 NCBI Official Synonym Full Names    annexin A6
 NCBI Official Symbol    ANXA6 [Similar Products]
 NCBI Official Synonym Symbols   
ANX6; CBP68
[Similar Products]
 NCBI Protein Information    annexin A6
 UniProt Protein Name    Annexin A6
 UniProt Synonym Protein Names   
67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70
 Protein Family    Annexin
 UniProt Gene Name    ANXA6 [Similar Products]
 UniProt Synonym Gene Names    ANX6; CPB-II [Similar Products]
 UniProt Entry Name    ANXA6_HUMAN
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 NCBI Summary for ANX6    Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
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 UniProt Comments for ANX6    ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Motility/polarity/chemotaxis; Calcium-binding

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: apical plasma membrane; focal adhesion; late endosome membrane; lysosomal membrane; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; protein complex; sarcolemma

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cholesterol binding; GTP binding; ligand-gated ion channel activity; lipid binding; protein binding; protein complex binding; protein homodimerization activity

Biological Process: calcium ion transport; mitochondrial calcium ion homeostasis; muscle contraction; protein homooligomerization; regulation of muscle contraction
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Product References and Citations for ANX6 recombinant protein

   Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.Crompton M.R., Owens R.J., Totty N.F., Moss S.E., Waterfield M.D., Crumpton M.J.EMBO J. 7:21-27(1988) Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.Suedhof T.C., Slaughter C.A., Leznicki I., Barjon P., Reynolds G.A.Proc. Natl. Acad. Sci. U.S.A. 85:664-668(1988) Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor.Iwasaki A., Suda M., Watanabe M., Nakao H., Hattori Y., Nagoya T., Saino Y., Shidara Y., Maki M.J. Biochem. 106:43-49(1989) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) The DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004)
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 Research Articles on ANX6    1. Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANX6 recombinant proteinPathways associated with ANX6 recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >7 publications with ANX6 and EGFR
 NPC1 recombinant protein  >4 publications with ANX6 and NPC1
 HRAS recombinant protein  >2 publications with ANX6 and HRAS
 RUNX2 recombinant protein  >1 publications with ANX6 and RUNX2
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
Diseases associated with ANX6 recombinant proteinOrgans/Tissues associated with ANX6 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with ANX6 and Nervous System Diseases
 Necrosis Antibodies  >4 publications with ANX6 and Necrosis
 Carcinoma Antibodies  >4 publications with ANX6 and Carcinoma
 Hypertrophy Antibodies  >3 publications with ANX6 and Hypertrophy
 Inflammation Antibodies  >3 publications with ANX6 and Inflammation
 Neoplasm Metastasis Antibodies  >3 publications with ANX6 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >3 publications with ANX6 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with ANX6 and Neoplasms, Experimental
 Lung Injury Antibodies  >1 publications with ANX6 and Lung Injury
 Lung Diseases Antibodies  >1 publications with ANX6 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ANX6 and Blood
 Bone Antibodies  >6 publications with ANX6 and Bone
 Skin Antibodies  >6 publications with ANX6 and Skin
 Muscle Antibodies  >5 publications with ANX6 and Muscle
 Connective Tissue Antibodies  >4 publications with ANX6 and Connective Tissue
 Heart Antibodies  >4 publications with ANX6 and Heart
 Liver Antibodies  >3 publications with ANX6 and Liver
 Uterus Antibodies  >2 publications with ANX6 and Uterus
 Vascular Antibodies  >2 publications with ANX6 and Vascular
 Eye Antibodies  >1 publications with ANX6 and Eye
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