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SERPINA1 recombinant protein :: Antitrypsin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203295
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Antitrypsin (SERPINA1), Recombinant Protein

 Also Known As   

Antitrypsin, 25-418aa, Human, Recombinant, E Coli

 Product Synonym Names    PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275; MGC23330; SERP1NA1; Alpha-1 antiproteinase; Serine proteinase inhibitor; Antitrypsin; Alpha 1 antiproteinase; Alpha 1 antitrypsin; alpha 1 AT; Alpha 1 protease inhibitor; alpha1 PI; MGC23330; alpha1 proteinase inhibitor; Clade A member 1; cysteine proteinase inhibitor; Serpin A1; Protease inhibitor 1; Serpin peptidase inhibitor clade A member 1; SerpinA1; Alpha-1 Antitrypsin; A1AT; serum trypsin inhibitor
 Product Gene Name   

SERPINA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MEDPQGDAAQ KTDTSHHDQD HPTFNKITPN LAEFAFSLYR QLAHQSNSTN IFFSPVSIAT AFAMLSLGTK ADTHDEILEG LNFNLTEIPE AQIHEGFQEL LRTLNQPDSQ LQLTTGNGLF LSEGLKLVDK FLEDVKKLYH SEAFTVNFGD TEEAKKQIND YVEKGTQGKI VDLVKELDRD TVFALVNYIF FKGKWERPFE VKDTEEEDFH VDQVTTVKVP MMKRLGMFNI QHCKKLSSWV LLMKYLGNAT AIFFLPDEGK LQHLENELTH DIITKFLENE DRRSASLHLP KLSITGTYDL KSVLGQLGIT KVFSNGADLS GVTEEAPLKL SKAVHKAVLT IDEKGTEAAG AMFLEAIPMS IPPEVKFNKP FVFLMIDQNT KSPLFMGKVV NPTQK
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid in 20mM Tris pH 7.5, 10% glycerol, 1mM DTT, 2mM EDTA
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SERPINA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SERPINA1 recombinant protein

   Alpha 1 proteinase inhibitor (Antitrypsin) has a characteristic secondary structure of beta sheets and alpha helices. That is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Also Increase in Antitrypsin occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Antitrypsin is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. Recombinant Antitrypsin protein was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for SERPINA1 recombinant protein    Serology
 Applications Tested/Suitable for SERPINA1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of SERPINA1 recombinant protein    SERPINA1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
 NCBI GI #    50363217
 NCBI GeneID    5265
 NCBI Accession #    NP_000286.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000295.4 [Other Products]
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 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 UniProt Related Accession #    P01009 [Other Products]
 Molecular Weight    44.4 kDa (395 aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    alpha-1-antitrypsin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
 NCBI Official Symbol    SERPINA1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
[Similar Products]
 NCBI Protein Information    alpha-1-antitrypsin; alpha-1 protease inhibitor; alpha-1-antiproteinase; alpha-1-antitrypsin null; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin A1
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1Short peptide from AAT; SPAAT
 Protein Family    Antitrypsin
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI; SPAAT [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for SERPINA1    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA1    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; response to methanol; response to hypoxia; acute-phase response; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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Product References and Citations for SERPINA1 recombinant protein

   Kolarich D., et al. (2006).Proteomics. 6(11):3369-80
Wu Y., et al. (1991).Bioessays. 13(4):163-9
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 Research Articles on SERPINA1    1. alpha-1 antitrypsin gene induction has a role in experimental and clinical acute kidney injury
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPINA1 recombinant proteinDiseases associated with SERPINA1 recombinant protein
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >131 publications with SERPINA1 and Lung Diseases
 alpha 1-Antitrypsin Deficiency Antibodies  >129 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >120 publications with SERPINA1 and Liver Diseases
 Pulmonary Disease, Chronic Obstructive Antibodies  >53 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
 Inflammation Antibodies  >36 publications with SERPINA1 and Inflammation
 Pulmonary Emphysema Antibodies  >36 publications with SERPINA1 and Pulmonary Emphysema
 Liver Cirrhosis Antibodies  >29 publications with SERPINA1 and Liver Cirrhosis
 Carcinoma, Hepatocellular Antibodies  >21 publications with SERPINA1 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >18 publications with SERPINA1 and Adenocarcinoma
 Hepatitis Antibodies  >18 publications with SERPINA1 and Hepatitis
Organs/Tissues associated with SERPINA1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >109 publications with SERPINA1 and Liver
 Blood Antibodies  >102 publications with SERPINA1 and Blood
 Lung Antibodies  >71 publications with SERPINA1 and Lung
 Skin Antibodies  >14 publications with SERPINA1 and Skin
 Vascular Antibodies  >11 publications with SERPINA1 and Vascular
 Heart Antibodies  >11 publications with SERPINA1 and Heart
 Kidney Antibodies  >10 publications with SERPINA1 and Kidney
 Pancreas Antibodies  >10 publications with SERPINA1 and Pancreas
 Bone Antibodies  >9 publications with SERPINA1 and Bone
 Muscle Antibodies  >8 publications with SERPINA1 and Muscle
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