NP_059109.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
apelin preproprotein
NCBI Official Synonym Full Names
apelin
NCBI Official Synonym Symbols
NCBI Protein Information
apelin
UniProt Protein Name
Apelin
UniProt Synonym Protein Names
APJ endogenous ligand
UniProt Synonym Gene Names
UniProt Entry Name
APEL_HUMAN
NCBI Summary for APLN
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
UniProt Comments for APLN
apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: extracellular space; extracellular region
Molecular Function: G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding
Biological Process: lactation; immune response; signal transduction
Research Articles on APLN
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Products associated with APLN recombinant protein
Pathways associated with APLN recombinant protein
Diseases associated with APLN recombinant protein
Organs/Tissues associated with APLN recombinant protein
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