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Apoc3 recombinant protein :: Apolipoprotein C-III Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962400
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $470 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $625 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $645 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $690 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $805 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $875 +1 FREE 8GB USB
1 mg (E-Coli)  /  $975 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $985 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,010 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,040 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,470 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,485 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,595 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,970 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein C-III (Apoc3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Apolipoprotein C-III

 Product Synonym Names    Apolipoprotein C3
 Product Gene Name   

Apoc3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS962400 COA    COA PDF
 Sequence Positions    21-99aa; Full Length
 Sequence    EEVEGSLLLG SVQGYMEQAS KTVQDALSSV QESDIAVVAR GWMDNHFRFL KGYWSKFTDK FTGFWDSNPE DQPTPAIES
 3D Structure    ModBase 3D Structure for P33622
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Apoc3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Apoc3 recombinant protein

   Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
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 SDS-Page of Apoc3 recombinant protein    Apoc3 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Apoc3. It may not necessarily be applicable to this product.
 NCBI GI #    577019554
 NCBI GeneID    11814
 NCBI Accession #    NP_001276685.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001289756.1 [Other Products]
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 UniProt Primary Accession #    P33622 [Other Products]
 UniProt Secondary Accession #    Q8VC58; Q9CPP9 [Other Products]
 UniProt Related Accession #    P33622 [Other Products]
 Molecular Weight    24.8kD
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 NCBI Official Full Name    apolipoprotein C-III isoform b
 NCBI Official Synonym Full Names    apolipoprotein C-III
 NCBI Official Symbol    Apoc3 [Similar Products]
 NCBI Official Synonym Symbols   
apo-CIII; apoC-III
[Similar Products]
 NCBI Protein Information    apolipoprotein C-III
 UniProt Protein Name    Apolipoprotein C-III
 UniProt Synonym Protein Names   
Apolipoprotein C3
 Protein Family    Apolipoprotein
 UniProt Gene Name    Apoc3 [Similar Products]
 UniProt Synonym Gene Names    Apo-CIII; ApoC-III [Similar Products]
 UniProt Entry Name    APOC3_MOUSE
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 NCBI Summary for Apoc3    This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for Apoc3    APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family.

Protein type: Secreted; Secreted, signal peptide; Lipid-binding

Cellular Component: cell; chylomicron; extracellular region; extracellular space

Molecular Function: lipase inhibitor activity; lipid binding; phospholipid binding

Biological Process: cholesterol homeostasis; cholesterol metabolic process; lipid catabolic process; lipid metabolic process; lipid transport; lipoprotein metabolic process; lipoprotein transport; negative regulation of lipoprotein lipase activity; response to peptide hormone stimulus; transport; triacylglycerol catabolic process; triacylglycerol metabolic process; triacylglycerol mobilization
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Product References and Citations for Apoc3 recombinant protein

   Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus genomic, mRNA, and protein sequences with comparisons to other species.Januzzi J.L., Azrolan N., O'Connell A., Aalto-Setala K., Breslow J.L.Genomics 14:1081-1088(1992) Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications.Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.Biochim. Biophys. Acta 1764:1363-1371(2006)
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 Research Articles on Apoc3    1. decreased ApoAI synthesis might be accounted for the lower plasma HDL level in ApoCIII transgenic mice
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Apoc3 recombinant proteinPathways associated with Apoc3 recombinant protein
 Reference Product  PubMed Publications
 Apoe recombinant protein  >82 publications with Apoc3 and Apoe
 Apoa5 recombinant protein  >81 publications with Apoc3 and Apoa5
 Apoa1 recombinant protein  >80 publications with Apoc3 and Apoa1
 Apob recombinant protein  >62 publications with Apoc3 and Apob
 Lpl recombinant protein  >56 publications with Apoc3 and Lpl
 Apoa4 recombinant protein  >49 publications with Apoc3 and Apoa4
 Apoc2 recombinant protein  >19 publications with Apoc3 and Apoc2
 Apoa2 recombinant protein  >16 publications with Apoc3 and Apoa2
 Ldlr recombinant protein  >13 publications with Apoc3 and Ldlr
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway antibodies  PPAR (Peroxisome Proliferator-activated Receptor) Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with Apoc3 recombinant proteinOrgans/Tissues associated with Apoc3 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >101 publications with Apoc3 and Cardiovascular Diseases
 Coronary Disease Antibodies  >70 publications with Apoc3 and Coronary Disease
 Heart Diseases Antibodies  >62 publications with Apoc3 and Heart Diseases
 Hypertriglyceridemia Antibodies  >54 publications with Apoc3 and Hypertriglyceridemia
 Dyslipidemias Antibodies  >52 publications with Apoc3 and Dyslipidemias
 Atherosclerosis Antibodies  >52 publications with Apoc3 and Atherosclerosis
 Insulin Resistance Antibodies  >43 publications with Apoc3 and Insulin Resistance
 Hyperlipidemias Antibodies  >41 publications with Apoc3 and Hyperlipidemias
 Fatty Liver Antibodies  >37 publications with Apoc3 and Fatty Liver
 Hyperinsulinism Antibodies  >32 publications with Apoc3 and Hyperinsulinism
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >67 publications with Apoc3 and Liver
 Intestine Antibodies  >10 publications with Apoc3 and Intestine
 Kidney Antibodies  >7 publications with Apoc3 and Kidney
 Muscle Antibodies  >5 publications with Apoc3 and Muscle
 Pancreas Antibodies  >3 publications with Apoc3 and Pancreas
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