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Apoe recombinant protein :: Apolipoprotein E Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955382
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $970 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,210 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,225 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,765 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,840 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,350 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein E (Apoe), Recombinant Protein

 Also Known As   

Recombinant Mouse Apolipoprotein E

 Product Gene Name   

Apoe recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS955382 COA    COA PDF
 Sequence Positions    19-311; Mature full length protein
 Sequence    EGEPEVTDQL EWQSNQPWEQ ALNRFWDYLR WVQTLSDQVQ EELQSSQVTQ ELTALMEDTM TEVKAYKKEL EEQLGPVAEE TRARLGKEVQ AAQARLGADM EDLRNRLGQY RNEVHTMLGQ STEEIRARLS THLRKMRKRL MRDAEDLQKR LAVYKAGARE GAERGVSAIR ERLGPLVEQG RQRTANLGAG AAQPLRDRAQ AFGDRIRGRL EEVGNQARDR LEEVREHMEE VRSKMEEQTQ QIRLQAEIFQ ARLKGWFEPI VEDMHRQWAN LMEKIQASVA TNPIITPVAQ ENQ
 3D Structure    ModBase 3D Structure for P08226
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Apoe recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Apoe recombinant protein

   Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
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 SDS-Page of Apoe recombinant protein    Apoe recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Apoe. It may not necessarily be applicable to this product.
 NCBI GI #    802084029
 NCBI GeneID    11816
 NCBI Accession #    NP_001292748.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001305819.1 [Other Products]
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 UniProt Primary Accession #    P08226 [Other Products]
 UniProt Related Accession #    P08226 [Other Products]
 Molecular Weight    38kD
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 NCBI Official Full Name    apolipoprotein E
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    Apoe [Similar Products]
 NCBI Official Synonym Symbols   
Apo-E; AI255918
[Similar Products]
 NCBI Protein Information    apolipoprotein E
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    Apoe [Similar Products]
 UniProt Synonym Gene Names    Apo-E [Similar Products]
 UniProt Entry Name    APOE_MOUSE
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 NCBI Summary for Apoe    This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]
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 UniProt Comments for Apoe    APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Cellular Component: cell soma; cell surface; chylomicron; cytoplasm; dendrite; early endosome; endoplasmic reticulum; endosome; extracellular matrix; extracellular region; extracellular space; extrinsic to external side of plasma membrane; Golgi apparatus; late endosome; lysosome; membrane; microtubule; nuclear envelope; nucleus; plasma membrane

Molecular Function: antioxidant activity; beta-amyloid binding; cholesterol binding; cholesterol transporter activity; heparin binding; hydroxyapatite binding; identical protein binding; lipid binding; lipid transporter activity; low-density lipoprotein receptor binding; metal chelating activity; phospholipid binding; protein binding; protein homodimerization activity; receptor binding; tau protein binding

Biological Process: aging; artery morphogenesis; axon regeneration; cellular calcium ion homeostasis; cGMP-mediated signaling; cholesterol biosynthetic process; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; fatty acid homeostasis; G-protein coupled receptor protein signaling pathway; lipid homeostasis; lipid metabolic process; lipid transport; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; long-chain fatty acid transport; maintenance of cellular localization; negative regulation of blood coagulation; negative regulation of blood vessel endothelial cell migration; negative regulation of cholesterol biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of lipid biosynthetic process; negative regulation of MAP kinase activity; negative regulation of neuron apoptosis; nitric oxide mediated signal transduction; phospholipid efflux; positive regulation of axon extension; positive regulation of cGMP biosynthetic process; positive regulation of lipid biosynthetic process; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric-oxide synthase activity; protein import; protein localization; receptor-mediated endocytosis; regulation of axon extension; regulation of Cdc42 protein signal transduction; regulation of cholesterol transport; regulation of gene expression; response to dietary excess; response to oxidative stress; reverse cholesterol transport; transport; triacylglycerol catabolic process; triacylglycerol metabolic process; vasodilation; virus assembly
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Product References and Citations for Apoe recombinant protein

   Structure and expression of mouse apolipoprotein E gene.Horiuchi K., Tajima S., Menju M., Yamamoto A.J. Biochem. 106:98-103(1989) Evolution of apolipoprotein E mouse sequence and evidence for an 11-nucleotide ancestral unit.Rajavashisth T.B., Kaptein J.S., Reue K.L., Lusis A.J.Proc. Natl. Acad. Sci. U.S.A. 82:8085-8089(1985) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.Diedrich J.F., Minnigan M., Carp R.I., Whitaker J.N., Race R., Frey W. II, Haase A.T.J. Virol. 65:4759-4768(1991) Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications.Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.Biochim. Biophys. Acta 1764:1363-1371(2006) Lubec G., Kang S.U.Submitted (APR-2007) to UniProtKB CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El Khoury J., Golenbock D.T., Moore K.J.Nat. Immunol. 11:155-161(2010)
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 Research Articles on Apoe    1. IL-9 exerted pro-atherosclerotic effects in ApoE-/- mice at least partially by inducing VCAM-1 expression, which mediated inflammatory cell infiltration into atherosclerotic lesions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Apoe recombinant proteinPathways associated with Apoe recombinant protein
 Reference Product  PubMed Publications
 Apob recombinant protein  >1519 publications with Apoe and Apob
 Ldlr recombinant protein  >602 publications with Apoe and Ldlr
 Lpl recombinant protein  >335 publications with Apoe and Lpl
 Apoc2 recombinant protein  >235 publications with Apoe and Apoc2
 Apoa1 recombinant protein  >162 publications with Apoe and Apoa1
 Lrp1 recombinant protein  >83 publications with Apoe and Lrp1
 Apoc3 recombinant protein  >82 publications with Apoe and Apoc3
 Hspg2 recombinant protein  >7 publications with Apoe and Hspg2
 Lrp2 recombinant protein  >5 publications with Apoe and Lrp2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with Apoe recombinant proteinOrgans/Tissues associated with Apoe recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6501 publications with Apoe and Cardiovascular Diseases
 Alzheimer Disease Antibodies  >5943 publications with Apoe and Alzheimer Disease
 Atherosclerosis Antibodies  >5241 publications with Apoe and Atherosclerosis
 Arteriosclerosis Antibodies  >4280 publications with Apoe and Arteriosclerosis
 Hyperlipidemias Antibodies  >1880 publications with Apoe and Hyperlipidemias
 Inflammation Antibodies  >1842 publications with Apoe and Inflammation
 Cognition Disorders Antibodies  >1507 publications with Apoe and Cognition Disorders
 Plaque, Atherosclerotic Antibodies  >1419 publications with Apoe and Plaque, Atherosclerotic
 Coronary Disease Antibodies  >1192 publications with Apoe and Coronary Disease
 Hypercholesterolemia Antibodies  >1084 publications with Apoe and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4693 publications with Apoe and Brain
 Liver Antibodies  >1973 publications with Apoe and Liver
 Heart Antibodies  >1714 publications with Apoe and Heart
 Muscle Antibodies  >1239 publications with Apoe and Muscle
 Bone Antibodies  >626 publications with Apoe and Bone
 Kidney Antibodies  >538 publications with Apoe and Kidney
 Bone Marrow Antibodies  >458 publications with Apoe and Bone Marrow
 Lung Antibodies  >306 publications with Apoe and Lung
 Spleen Antibodies  >260 publications with Apoe and Spleen
 Adipose Tissue Antibodies  >252 publications with Apoe and Adipose Tissue
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