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SIVA1 recombinant protein :: Apoptosis regulatory protein Siva Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1132006
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $825 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,065 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,510 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,630 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,025 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apoptosis regulatory protein Siva (SIVA1), Recombinant Protein

 Also Known As   

Recombinant Human Apoptosis regulatory protein Siva

 Product Synonym Names    CD27-binding protein; CD27BP
 Product Gene Name   

SIVA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-110aa; Full Length of Isoform 2
 Sequence    MPKRSCPFAD VAPLQLKVRV SQRELSRGVC AERYSQEVFD PSGVASIACS SCVRAVDGKA VCGQCERALC GQCVRTCWGC GSVACTLCGL VDCSDMYEKV LCTSCAMFET
 OMIM    605567
 3D Structure    ModBase 3D Structure for O15304
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SIVA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SIVA1 recombinant protein

   Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
 Product Categories/Family for SIVA1 recombinant protein    Cell Biology
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 SDS-Page of SIVA1 recombinant protein    SIVA1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SIVA1. It may not necessarily be applicable to this product.
 NCBI GI #    11277468
 NCBI GeneID    10572
 NCBI Accession #    NP_006418.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006427.3 [Other Products]
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 UniProt Primary Accession #    O15304 [Other Products]
 UniProt Secondary Accession #    Q96P98; Q9UPD6 [Other Products]
 UniProt Related Accession #    O15304 [Other Products]
 Molecular Weight    27.8kD
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 NCBI Official Full Name    apoptosis regulatory protein Siva isoform 1
 NCBI Official Synonym Full Names    SIVA1 apoptosis inducing factor
 NCBI Official Symbol    SIVA1 [Similar Products]
 NCBI Official Synonym Symbols   
SIVA; CD27BP; Siva-1; Siva-2
[Similar Products]
 NCBI Protein Information    apoptosis regulatory protein Siva
 UniProt Protein Name    Apoptosis regulatory protein Siva
 UniProt Synonym Protein Names   
CD27-binding protein; CD27BP
 Protein Family    Apoptosis regulatory protein
 UniProt Gene Name    SIVA1 [Similar Products]
 UniProt Synonym Gene Names    SIVA; CD27BP [Similar Products]
 UniProt Entry Name    SIVA_HUMAN
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 NCBI Summary for SIVA1    This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIVA1    Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm; mitochondrion; nucleoplasm

Molecular Function: CD27 receptor binding; metal ion binding; protein binding; viral receptor activity; zinc ion binding

Biological Process: activated T cell apoptosis; entry of virus into host cell; inhibition of NF-kappaB transcription factor
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Product References and Citations for SIVA1 recombinant protein

   CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) Characterization of TPA-responsive genes in U937 cells using ordered differential display PCR.Kang H.S., Park Y.J., Jung H.M., Jun D.Y., Huh T.L., Kim Y.H. Apoptosis in coxsackievirus B3-caused diseases interaction between the capsid protein VP2 and the proapoptotic protein siva.Henke A., Launhardt H., Klement K., Stelzner A., Zell R., Munder T.J. Virol. 74:4284-4290(2000) The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.Cao C., Ren X., Kharbanda S., Koleske A., Prasad K.V.S., Kufe D.J. Biol. Chem. 276:11465-11468(2001) The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.Henke A., Nestler M., Strunze S., Saluz H.-P., Hortschansky P., Menzel B., Martin U., Zell R., Stelzner A., Munder T.Virology 289:15-22(2001) Siva-1 binds to and inhibits BCL-X(L) -mediated protection against UV radiation-induced apoptosis.Xue L., Chu F., Cheng Y., Sun X., Borthakur A., Ramarao M., Pandey P., Wu M., Schlossman S.F., Prasad K.V.S.Proc. Natl. Acad. Sci. U.S.A. 99:6925-6930(2002) The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.Chu F., Borthakur A., Sun X., Barkinge J., Gudi R., Hawkins S., Prasad K.V.S.Apoptosis 9:83-95(2004) Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.Py B., Slomianny C., Auberger P., Petit P.X., Benichou S.J. Immunol. 172:4008-4017(2004) Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells effect of elevated levels of BCL-2.Chu F., Barkinge J., Hawkins S., Gudi R., Salgia R., Kanteti P.V.S.Cancer Res. 65:5301-5309(2005) The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.Nestler M., Martin U., Hortschansky P., Saluz H.-P., Henke A., Munder T.Mol. Cell. Biochem. 287:147-155(2006) Siva-1 negatively regulates NF-kappaB activity effect on T-cell receptor-mediated activation-induced cell death (AICD) .Gudi R., Barkinge J., Hawkins S., Chu F., Manicassamy S., Sun Z., Duke-Cohan J.S., Prasad K.V.S.Oncogene 25:3458-3462(2006) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)
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 Research Articles on SIVA1    1. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIVA1 recombinant proteinDiseases associated with SIVA1 recombinant protein
 Reference Product  PubMed Publications
 CD27 recombinant protein  >12 publications with SIVA1 and CD27
 BCL2L1 recombinant protein  >7 publications with SIVA1 and BCL2L1
 MDM2 recombinant protein  >5 publications with SIVA1 and MDM2
 PCNA recombinant protein  >3 publications with SIVA1 and PCNA
 XIAP recombinant protein  >2 publications with SIVA1 and XIAP
 TP53 recombinant protein  >2 publications with SIVA1 and TP53
 RAD18 recombinant protein  >1 publications with SIVA1 and RAD18
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >7 publications with SIVA1 and Necrosis
 Coxsackievirus Infections Antibodies  >4 publications with SIVA1 and Coxsackievirus Infections
 Cardiovascular Diseases Antibodies  >3 publications with SIVA1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >3 publications with SIVA1 and Lung Diseases
 Inflammation Antibodies  >3 publications with SIVA1 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with SIVA1 and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with SIVA1 and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with SIVA1 and Disease Models, Animal
 Vascular Diseases Antibodies  >2 publications with SIVA1 and Vascular Diseases
 Fever Antibodies  >2 publications with SIVA1 and Fever
Organs/Tissues associated with SIVA1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with SIVA1 and Blood
 Heart Antibodies  >4 publications with SIVA1 and Heart
 Lung Antibodies  >3 publications with SIVA1 and Lung
 Kidney Antibodies  >2 publications with SIVA1 and Kidney
 Muscle Antibodies  >2 publications with SIVA1 and Muscle
 Bone Antibodies  >1 publications with SIVA1 and Bone
 Eye Antibodies  >1 publications with SIVA1 and Eye
 Embryonic Tissue Antibodies  >1 publications with SIVA1 and Embryonic Tissue
 Skin Antibodies  >1 publications with SIVA1 and Skin
 Thymus Antibodies  >1 publications with SIVA1 and Thymus
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