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Apaf1 recombinant protein :: Apoptotic protease-activating factor 1 (Apaf1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1123162 Apaf1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apoptotic protease-activating factor 1 (Apaf1), Recombinant Protein

 Also Known As   

Recombinant Mouse Apoptotic protease-activating factor 1 (Apaf1) , partial

 Product Gene Name   

Apaf1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O88879
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Apaf1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Apaf1 recombinant protein

   This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for Apaf1. It may not necessarily be applicable to this product.
 NCBI GI #    110347465
 NCBI GeneID    11783
 NCBI Accession #    NP_001036023.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042558.1 [Other Products]
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 UniProt Primary Accession #    O88879 [Other Products]
 UniProt Secondary Accession #    A2RRK8 [Other Products]
 UniProt Related Accession #    O88879 [Other Products]
 Molecular Weight    139,896 Da
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 NCBI Official Full Name    apoptotic protease-activating factor 1 isoform 1
 NCBI Official Synonym Full Names    apoptotic peptidase activating factor 1
 NCBI Official Symbol    Apaf1 [Similar Products]
 NCBI Official Synonym Symbols   
fog; Apaf-1; Apaf1l; mKIAA0413; 6230400I06Rik
[Similar Products]
 NCBI Protein Information    apoptotic protease-activating factor 1
 UniProt Protein Name    Apoptotic protease-activating factor 1
 Protein Family    Apoptotic protease-activating factor
 UniProt Gene Name    Apaf1 [Similar Products]
 UniProt Synonym Gene Names    APAF-1 [Similar Products]
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 UniProt Comments for Apaf1    Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP ().
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 Research Articles on Apaf1    1. miR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Apaf1 recombinant proteinPathways associated with Apaf1 recombinant protein
 Reference Product  PubMed Publications
 Casp9 recombinant protein  >449 publications with Apaf1 and Casp9
 Casp3 recombinant protein  >348 publications with Apaf1 and Casp3
 Bcl2l1 recombinant protein  >64 publications with Apaf1 and Bcl2l1
 Casp7 recombinant protein  >37 publications with Apaf1 and Casp7
 Bak1 recombinant protein  >22 publications with Apaf1 and Bak1
 Hsp90ab1 recombinant protein  >2 publications with Apaf1 and Hsp90ab1
 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with Apaf1 recombinant proteinOrgans/Tissues associated with Apaf1 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >96 publications with Apaf1 and Necrosis
 Disease Models, Animal Antibodies  >32 publications with Apaf1 and Disease Models, Animal
 Inflammation Antibodies  >29 publications with Apaf1 and Inflammation
 Liver Diseases Antibodies  >29 publications with Apaf1 and Liver Diseases
 Breast Neoplasms Antibodies  >28 publications with Apaf1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >21 publications with Apaf1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >19 publications with Apaf1 and Carcinoma, Hepatocellular
 Colonic Neoplasms Antibodies  >18 publications with Apaf1 and Colonic Neoplasms
 Kidney Diseases Antibodies  >16 publications with Apaf1 and Kidney Diseases
 Lung Neoplasms Antibodies  >16 publications with Apaf1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >114 publications with Apaf1 and Brain
 Blood Antibodies  >91 publications with Apaf1 and Blood
 Liver Antibodies  >54 publications with Apaf1 and Liver
 Lung Antibodies  >34 publications with Apaf1 and Lung
 Embryonic Tissue Antibodies  >32 publications with Apaf1 and Embryonic Tissue
 Eye Antibodies  >28 publications with Apaf1 and Eye
 Skin Antibodies  >28 publications with Apaf1 and Skin
 Thymus Antibodies  >14 publications with Apaf1 and Thymus
 Bone Marrow Antibodies  >13 publications with Apaf1 and Bone Marrow
 Ovary Antibodies  >12 publications with Apaf1 and Ovary
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