NP_001163960.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,015 Da
NCBI Official Full Name
aprataxin and PNK-like factor isoform 1
NCBI Official Synonym Full Names
aprataxin and PNKP like factor
NCBI Protein Information
aprataxin and PNK-like factor
UniProt Protein Name
Aprataxin and PNK-like factor
UniProt Synonym Protein Names
Apurinic-apyrimidinic endonuclease APLF
UniProt Comments for Aplf
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage ().
Research Articles on Aplf
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Diseases associated with Aplf recombinant protein
Organs/Tissues associated with Aplf recombinant protein
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