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| Product Name
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Aquaporin-3 (AQP3), Recombinant Protein ★Popular Item★
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| Also Known As
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Recombinant Human Aquaporin-3 (AQP3)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| MBS7007875 COA
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| Sequence Positions
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1-292aa; full length protein
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| Sequence
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MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQFIGTAS LIVCVLAIVD PYNNPVPRGL EAFTVGLVVL VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ HWWWVPIVSP LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI
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| OMIM
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600170
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| 3D Structure
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ModBase 3D Structure for Q92482
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| Host
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Cell Free Expression
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| Form/Format
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Liquid containing glycerol
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| Species
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Human
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| Storage Buffer
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Tris-based buffer, 50% glycerol.
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| Tag Information
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Tag type will be determined during the manufacturing process.
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| Preparation and Storage
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Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of AQP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for AQP3 recombinant protein
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Transmembrane Protein
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| Application Notes for AQP3 recombinant protein
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This is a recombinant transmembrane protein expressed in a cell-free expression system.
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TOP
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| NCBI/Uniprot data below describe general gene information for AQP3. It may not necessarily be applicable to this product. |
| NCBI GI #
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970259826
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| NCBI GeneID
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360
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| NCBI Accession #
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NP_001305073.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001318144.1
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[Other Products]
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| UniProt Primary Accession #
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Q92482
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[Other Products]
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| UniProt Secondary Accession #
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O00108; Q6FGT2; Q6FGW6; A8K843; B2RE16; D3DRL3
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[Other Products]
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| UniProt Related Accession #
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Q92482
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[Other Products]
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| Molecular Weight
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29,987 Da
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TOP
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| NCBI Official Full Name
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aquaporin-3 isoform 2
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| NCBI Official Synonym Full Names
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aquaporin 3 (Gill blood group)
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| NCBI Official Symbol
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AQP3
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[Similar Products]
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| NCBI Official Synonym Symbols
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GIL; AQP-3
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[Similar Products]
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| NCBI Protein Information
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aquaporin-3
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| UniProt Protein Name
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Aquaporin-3
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| UniProt Synonym Protein Names
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Aquaglyceroporin-3
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| Protein Family
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Aquaporin
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| UniProt Gene Name
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AQP3
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[Similar Products]
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| UniProt Synonym Gene Names
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AQP-3
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[Similar Products]
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| UniProt Entry Name
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AQP3_HUMAN
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| NCBI Summary for AQP3
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This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
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| UniProt Comments for AQP3
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AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family; Transporter
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: basolateral plasma membrane; cytoplasm; integral to membrane; integral to plasma membrane; intercellular junction; nucleus; plasma membrane
Molecular Function: glycerol channel activity; transporter activity; urea transmembrane transporter activity; water channel activity
Biological Process: cellular water homeostasis; excretion; glycerol transport; odontogenesis; positive regulation of immune system process; regulation of keratinocyte differentiation; renal water homeostasis; response to calcium ion; response to retinoic acid; response to vitamin D; transport; water transport
Disease: Gil Blood Group
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TOP
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| Research Articles on AQP3
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1. the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with AQP3 recombinant protein | Diseases associated with AQP3 recombinant protein |
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| Organs/Tissues associated with AQP3 recombinant protein |
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TOP
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Recombinant Protein 
