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AQP4 recombinant protein :: Aquaporin-4 (AQP4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960179
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $225 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $290 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $495 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $795 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $795 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,000 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,035 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,460 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,585 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,955 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,065 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aquaporin-4 (AQP4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Aquaporin-4 (AQP4), partial

 Product Synonym Names    Mercurial-insensitive water channel; MIWC WCH4
 Product Gene Name   

AQP4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS960179 COA    COA PDF
 Sequence Positions    253-323. Partial.
 Sequence    CPDVEFKRRF KEAFSKAAQQ TKGSYMEVED NRSQVETDDL ILKPGVVHVI DVDRGEEKKG KDQSGEVLSS V
 OMIM    600308
 3D Structure    ModBase 3D Structure for P55087
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AQP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AQP4 recombinant protein

   Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
 Product Categories/Family for AQP4 recombinant protein    Transport
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 SDS-Page of AQP4 recombinant protein    AQP4 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for AQP4. It may not necessarily be applicable to this product.
 NCBI GI #    4502181
 NCBI GeneID    361
 NCBI Accession #    NP_001641.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001650.5 [Other Products]
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 UniProt Primary Accession #    P55087 [Other Products]
 UniProt Secondary Accession #    P78564 [Other Products]
 UniProt Related Accession #    P55087 [Other Products]
 Molecular Weight    23.98kD
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 NCBI Official Full Name    aquaporin-4 isoform M1
 NCBI Official Synonym Full Names    aquaporin 4
 NCBI Official Symbol    AQP4 [Similar Products]
 NCBI Official Synonym Symbols   
MIWC; WCH4
[Similar Products]
 NCBI Protein Information    aquaporin-4
 UniProt Protein Name    Aquaporin-4
 UniProt Synonym Protein Names   
Mercurial-insensitive water channel; MIWC; WCH4
 Protein Family    Aquaporin
 UniProt Gene Name    AQP4 [Similar Products]
 UniProt Synonym Gene Names    AQP-4; MIWC [Similar Products]
 UniProt Entry Name    AQP4_HUMAN
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 NCBI Summary for AQP4    This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
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 UniProt Comments for AQP4    AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Channel, misc.; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function: glycerol channel activity; water channel activity; water transporter activity

Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport
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Product References and Citations for AQP4 recombinant protein

   cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.Yang B., Ma T., Verkman A.S.J. Biol. Chem. 270:22907-22913(1995) A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.Misaka T., Abe K., Iwabuchi K., Kusakabe Y., Ichinose M., Miki K., Emori Y., Arai S.FEBS Lett. 381:208-212(1996) The human AQP4 gene definition of the locus encoding two water channel polypeptides in brain.Lu M., Lee M.D., Smith B.L., Jung J.S., Agre P., Verdijk M.A.J., Merkx G., Rijss J.P.L., Deen P.M.T.Proc. Natl. Acad. Sci. U.S.A. 93:10908-10912(1996) DNA sequence and analysis of human chromosome 18.Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.Nature 437:551-555(2005) Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress dysregulation by pathological mutations.Lanciotti A., Brignone M.S., Molinari P., Visentin S., De Nuccio C., Macchia G., Aiello C., Bertini E., Aloisi F., Petrucci T.C., Ambrosini E.Hum. Mol. Genet. 21:2166-2180(2012) Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.Ho J.D., Yeh R., Sandstrom A., Chorny I., Harries W.E., Robbins R.A., Miercke L.J., Stroud R.M.Proc. Natl. Acad. Sci. U.S.A. 106:7437-7442(2009)
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 Research Articles on AQP4    1. Phosphorylation at serine 276 is necessary for AQP4 translocation in response to changes of tonicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AQP4 recombinant proteinPathways associated with AQP4 recombinant protein
 Reference Product  PubMed Publications
 AQP2 recombinant protein  >148 publications with AQP4 and AQP2
 KCNJ10 recombinant protein  >47 publications with AQP4 and KCNJ10
 AVP recombinant protein  >18 publications with AQP4 and AVP
 TRPV4 recombinant protein  >4 publications with AQP4 and TRPV4
 HMOX1 recombinant protein  >1 publications with AQP4 and HMOX1
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
Diseases associated with AQP4 recombinant proteinOrgans/Tissues associated with AQP4 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1092 publications with AQP4 and Nervous System Diseases
 Neuromyelitis Optica Antibodies  >682 publications with AQP4 and Neuromyelitis Optica
 Brain Diseases Antibodies  >555 publications with AQP4 and Brain Diseases
 Edema Antibodies  >510 publications with AQP4 and Edema
 Disease Models, Animal Antibodies  >246 publications with AQP4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >204 publications with AQP4 and Cardiovascular Diseases
 Inflammation Antibodies  >141 publications with AQP4 and Inflammation
 Necrosis Antibodies  >53 publications with AQP4 and Necrosis
 Kidney Diseases Antibodies  >42 publications with AQP4 and Kidney Diseases
 Hypertension Antibodies  >36 publications with AQP4 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1092 publications with AQP4 and Brain
 Spinal Cord Antibodies  >324 publications with AQP4 and Spinal Cord
 Nerve Antibodies  >240 publications with AQP4 and Nerve
 Vascular Antibodies  >203 publications with AQP4 and Vascular
 Kidney Antibodies  >167 publications with AQP4 and Kidney
 Eye Antibodies  >148 publications with AQP4 and Eye
 Muscle Antibodies  >121 publications with AQP4 and Muscle
 Lung Antibodies  >70 publications with AQP4 and Lung
 Intestine Antibodies  >32 publications with AQP4 and Intestine
 Embryonic Tissue Antibodies  >28 publications with AQP4 and Embryonic Tissue
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