NP_695213.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
76,145 Da
NCBI Official Full Name
arachidonate 15-lipoxygenase B
NCBI Official Synonym Full Names
arachidonate 15-lipoxygenase, type B
NCBI Protein Information
arachidonate 15-lipoxygenase B
UniProt Protein Name
Arachidonate 15-lipoxygenase B
UniProt Synonym Protein Names
15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb (EC:1.13.11.-)
UniProt Synonym Gene Names
NCBI Summary for Alox15b
human homolog is an epidermis-type lipoxygenase and member of the multigene family of mammalian lipoxygenases [RGD, Feb 2006]
UniProt Comments for Alox15b
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Research Articles on Alox15b
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Products associated with Alox15b recombinant protein
Pathways associated with Alox15b recombinant protein
Diseases associated with Alox15b recombinant protein
Organs/Tissues associated with Alox15b recombinant protein
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