NP_001163.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
arginase-2, mitochondrial
NCBI Official Synonym Full Names
arginase 2
NCBI Protein Information
arginase-2, mitochondrial; L-arginine amidinohydrolase; L-arginine ureahydrolase; arginase, type II; kidney arginase; kidney-type arginase; non-hepatic arginase; nonhepatic arginase; type II arginase
UniProt Protein Name
Arginase-2, mitochondrial
UniProt Synonym Protein Names
Kidney-type arginase; Non-hepatic arginase; Type II arginase
UniProt Entry Name
ARGI2_HUMAN
NCBI Summary for ARG2
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ARG2
ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family.
Protein type: EC 3.5.3.1; Amino Acid Metabolism - arginine and proline; Mitochondrial; Hydrolase
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: metal ion binding; arginase activity
Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle
Research Articles on ARG2
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Products associated with ARG2 recombinant protein
Pathways associated with ARG2 recombinant protein
Diseases associated with ARG2 recombinant protein
Organs/Tissues associated with ARG2 recombinant protein
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