NP_001527.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein arginine N-methyltransferase 1 isoform 1
NCBI Official Synonym Full Names
protein arginine methyltransferase 1
NCBI Protein Information
protein arginine N-methyltransferase 1
UniProt Protein Name
Protein arginine N-methyltransferase 1
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4
UniProt Synonym Gene Names
UniProt Entry Name
ANM1_HUMAN
NCBI Summary for PRMT1
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
UniProt Comments for PRMT1
PRMT1: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP. Widely expressed. By BTG1, BTG2 and ILF3. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Methyltransferase; Methyltransferase, protein arginine; EC 2.1.1.125
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: enzyme binding; histone methyltransferase activity; identical protein binding; methyl-CpG binding; methyltransferase activity; mitogen-activated protein kinase p38 binding; N-methyltransferase activity; protein binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity
Biological Process: cell surface receptor linked signal transduction; establishment and/or maintenance of chromatin architecture; histone methylation; negative regulation of megakaryocyte differentiation; neurite development; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; peptidyl-arginine N-methylation; positive regulation of erythrocyte differentiation; positive regulation of hemoglobin biosynthetic process; protein amino acid methylation; regulation of transcription, DNA-dependent
Product References and Citations for PRMT1 recombinant protein
Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)
Research Articles on PRMT1
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Products associated with PRMT1 recombinant protein
Pathways associated with PRMT1 recombinant protein
Diseases associated with PRMT1 recombinant protein
Organs/Tissues associated with PRMT1 recombinant protein
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