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ARNT recombinant protein :: Aryl hydrocarbon receptor nuclear translocator (ARNT) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS968128
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $895 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,105 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,320 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,355 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,405 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,875 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,015 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,045 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,650 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aryl hydrocarbon receptor nuclear translocator (ARNT), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Aryl hydrocarbon receptor nuclear translocator (ARNT), partial

 Product Gene Name   

ARNT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS968128 COA    COA PDF
 Sequence Positions    1-474aa, Partial
 Sequence    MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY SDEIEYIICT NTNVKNSSQE PRPT
 OMIM    126110
 3D Structure    ModBase 3D Structure for P27540
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ARNT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ARNT recombinant protein

   The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
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 SDS-Page of ARNT recombinant protein    ARNT recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ARNT. It may not necessarily be applicable to this product.
 NCBI GI #    309747071
 NCBI GeneID    405
 NCBI Accession #    NP_001184254.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001197325.1 [Other Products]
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 UniProt Primary Accession #    P27540 [Other Products]
 UniProt Secondary Accession #    Q59ED4; Q5QP39; Q8NDC7; B2R9H1; C4AMA1; F8WAP6 [Other Products]
 UniProt Related Accession #    P27540 [Other Products]
 Molecular Weight    54.83kD
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 NCBI Official Full Name    aryl hydrocarbon receptor nuclear translocator isoform 4
 NCBI Official Synonym Full Names    aryl hydrocarbon receptor nuclear translocator
 NCBI Official Symbol    ARNT [Similar Products]
 NCBI Official Synonym Symbols   
HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
[Similar Products]
 NCBI Protein Information    aryl hydrocarbon receptor nuclear translocator
 UniProt Protein Name    Aryl hydrocarbon receptor nuclear translocator
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta
 Protein Family    Aryl hydrocarbon receptor nuclear translocator
 UniProt Gene Name    ARNT [Similar Products]
 UniProt Synonym Gene Names    BHLHE2; ARNT protein; bHLHe2; HIF-1-beta; HIF1-beta [Similar Products]
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 NCBI Summary for ARNT    This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
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 UniProt Comments for ARNT    Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
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 Research Articles on ARNT    1. Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARNT recombinant proteinPathways associated with ARNT recombinant protein
 Reference Product  PubMed Publications
 AHR recombinant protein  >590 publications with ARNT and AHR
 HIF1A recombinant protein  >260 publications with ARNT and HIF1A
 ARNT2 recombinant protein  >54 publications with ARNT and ARNT2
 SIM1 recombinant protein  >14 publications with ARNT and SIM1
 SIM2 recombinant protein  >12 publications with ARNT and SIM2
 NCOA1 recombinant protein  >10 publications with ARNT and NCOA1
 AIP recombinant protein  >10 publications with ARNT and AIP
 EPAS1 recombinant protein  >9 publications with ARNT and EPAS1
 NPAS4 recombinant protein  >6 publications with ARNT and NPAS4
 NCOA2 recombinant protein  >5 publications with ARNT and NCOA2
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway antibodies  Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway Diagram
Diseases associated with ARNT recombinant proteinOrgans/Tissues associated with ARNT recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >242 publications with ARNT and Neoplasms
 Drug Toxicity Antibodies  >157 publications with ARNT and Drug Toxicity
 Liver Diseases Antibodies  >91 publications with ARNT and Liver Diseases
 Liver Neoplasms Antibodies  >87 publications with ARNT and Liver Neoplasms
 Nervous System Diseases Antibodies  >54 publications with ARNT and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >51 publications with ARNT and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >50 publications with ARNT and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >44 publications with ARNT and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >41 publications with ARNT and Breast Neoplasms
 Liver Neoplasms, Experimental Antibodies  >33 publications with ARNT and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >236 publications with ARNT and Liver
 Brain Antibodies  >188 publications with ARNT and Brain
 Blood Antibodies  >149 publications with ARNT and Blood
 Vascular Antibodies  >148 publications with ARNT and Vascular
 Muscle Antibodies  >119 publications with ARNT and Muscle
 Heart Antibodies  >73 publications with ARNT and Heart
 Lung Antibodies  >70 publications with ARNT and Lung
 Kidney Antibodies  >61 publications with ARNT and Kidney
 Embryonic Tissue Antibodies  >58 publications with ARNT and Embryonic Tissue
 Ovary Antibodies  >35 publications with ARNT and Ovary
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