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NAT2 recombinant protein :: Arylamine N-acetyltransferase 2 (NAT2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS964533
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $825 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $970 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,110 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,210 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,220 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,255 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,760 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,835 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,905 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,345 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Arylamine N-acetyltransferase 2 (NAT2), Recombinant Protein

 Also Known As   

Recombinant Human Arylamine N-acetyltransferase 2 (NAT2)

 Product Synonym Names    Arylamine N-acetyltransferase 2; EC=2.3.1.5; Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2; Polymorphic arylamine N-acetyltransferase; PNAT
 Product Gene Name   

NAT2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    NAT2; AAC2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-290aa; Full Length
 Sequence    MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI
 OMIM    612182
 3D Structure    ModBase 3D Structure for P11245
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NAT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NAT2 recombinant protein

   Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
 Product Categories/Family for NAT2 recombinant protein    Signal Transduction
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 SDS-PAGE of NAT2 recombinant protein    NAT2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for NAT2. It may not necessarily be applicable to this product.
 NCBI GI #    116295260
 NCBI GeneID    10
 NCBI Accession #    NP_000006.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000015.2 [Other Products]
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 UniProt Primary Accession #    P11245 [Other Products]
 UniProt Secondary Accession #    O43637; O60654; O60655; Q13146; Q16697; Q2MLE4; Q2MLF5; Q2MLG8; Q2MLJ6; Q2MLK4; Q2MLK6 [Other Products]
 UniProt Related Accession #    P11245 [Other Products]
 Molecular Weight    33,542 Da
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 NCBI Official Full Name    arylamine N-acetyltransferase 2
 NCBI Official Synonym Full Names    N-acetyltransferase 2 (arylamine N-acetyltransferase)
 NCBI Official Symbol    NAT2 [Similar Products]
 NCBI Official Synonym Symbols   
AAC2; PNAT; NAT-2
[Similar Products]
 NCBI Protein Information    arylamine N-acetyltransferase 2; arylamide acetylase 2; N-acetyltransferase type 2
 UniProt Protein Name    Arylamine N-acetyltransferase 2
 UniProt Synonym Protein Names   
Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2; Polymorphic arylamine N-acetyltransferase; PNAT
 Protein Family    Arylamine N-acetyltransferase
 UniProt Gene Name    NAT2 [Similar Products]
 UniProt Synonym Gene Names    AAC2; NAT-2; PNAT [Similar Products]
 UniProt Entry Name    ARY2_HUMAN
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 NCBI Summary for NAT2    This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
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 UniProt Comments for NAT2    NAT2: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family.

Protein type: Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes; Acetyltransferase; EC 2.3.1.5; Translation

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cytosol

Molecular Function: arylamine N-acetyltransferase activity

Biological Process: xenobiotic metabolic process

Disease: Acetylation, Slow
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 Research Articles on NAT2    1. NAT2 polymorphism significantly modifies the effects of alcohol use and black tea consumption on systemic lupus erythematosus (SLE), emphasizing the importance of incorporating genetic and metabolic information in studies on management of SLE
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NAT2 recombinant proteinDiseases associated with NAT2 recombinant protein
 Products by Pathway  Pathway Diagram
 Acetylation Pathway antibodies  Acetylation Pathway Diagram
 Arylamine Metabolism Pathway antibodies  Arylamine Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Disease Name  Pubmed Publications
 Urinary Bladder Neoplasms Antibodies  >130 publications with NAT2 and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >84 publications with NAT2 and Liver Diseases
 Breast Neoplasms Antibodies  >83 publications with NAT2 and Breast Neoplasms
 Drug-Related Side Effects and Adverse Reactions Antibodies  >66 publications with NAT2 and Drug-Related Side Effects and Adverse Reactions
 Lung Neoplasms Antibodies  >59 publications with NAT2 and Lung Neoplasms
 Drug-Induced Liver Injury Antibodies  >55 publications with NAT2 and Drug-Induced Liver Injury
 Adenocarcinoma Antibodies  >46 publications with NAT2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >41 publications with NAT2 and Liver Neoplasms
 Carcinoma, Squamous Cell Antibodies  >37 publications with NAT2 and Carcinoma, Squamous Cell
 Colonic Neoplasms Antibodies  >33 publications with NAT2 and Colonic Neoplasms
Organs/Tissues associated with NAT2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >238 publications with NAT2 and Liver
 Intestine Antibodies  >38 publications with NAT2 and Intestine
 Bone Antibodies  >6 publications with NAT2 and Bone
 Connective Tissue Antibodies  >1 publications with NAT2 and Connective Tissue
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