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ASPH recombinant protein :: Aspartate Beta-Hydroxylase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143742 ASPH recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aspartate Beta-Hydroxylase (ASPH), Recombinant Protein

 Also Known As   

Recombinant Human Aspartate Beta-Hydroxylase

 Product Synonym Names    ASPH Human; Aspartate Beta-Hydroxylase Human Recombinant; AAH; BAH; CASQ2BP1; HAAH; JCTN; Junctin; EC 1.14.11.16; Aspartyl/asparaginyl beta-hydroxylase; Aspartate beta-hydroxylase; Peptide-aspartate beta-dioxygenase; ASP beta-hydroxylase; ASPH
 Product Gene Name   

ASPH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MFDLVD YEEV LGKLGIYDAD GDGDFDVDDA KVLLGLKERS TSEPAVPPEE AEPHTEPEEQ VPVEAEPQNI EDEAKEQIQS LLHEMVHAEH ETEHSYHVEE TVSQDCNQDM EEMMSEQENP DSSEPVVEDE RLHHDTDDVT YQVYEEQAVY EPLENEGIEI TEVTAPPEDN PVEDSQVIVE EVSIFPVEEQ QEVPPDT
 OMIM    600582
 3D Structure    ModBase 3D Structure for Q12797
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The ASPH protein solution contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    ASPH although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of ASPH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ASPH recombinant protein

   Description: ASPH Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 217 amino acids (75-270 a.a.) and having a molecular mass of 24.5 kDa. The ASPH is fused to a 20 amino acid His Tag and purified by conventional chromatography.

Introduction: ASPH hydroxylates an Asp or Asn residue in EGF domains. ASPH is involved in calcium homeostasis. ASPH is expressed from two promoters and goes through extensive alternative splicing. The encoded set of ASPH proteins share varying quantities of overlap near their N-termini although have considerable differences in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the EGF domain, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Further isoforms diverge mainly in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum.
 Product Categories/Family for ASPH recombinant protein    ENZYMES; Enzymes; Hydroxylase
NCBI/Uniprot data below describe general gene information for ASPH. It may not necessarily be applicable to this product.
 NCBI GI #    258613943
 NCBI GeneID    444
 NCBI Accession #    NP_001158222.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001164750.1 [Other Products]
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 UniProt Primary Accession #    Q12797 [Other Products]
 UniProt Secondary Accession #    Q6NXR7; Q8TB28; Q9H291; Q9H2C4; A6NDF4; A6NHI2; B4DIC9; B4E2K4; B7ZM95; E5RGP5; F5H667 [Other Products]
 UniProt Related Accession #    Q12797 [Other Products]
 Molecular Weight    28,926 Da
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 NCBI Official Full Name    aspartyl/asparaginyl beta-hydroxylase isoform f
 NCBI Official Synonym Full Names    aspartate beta-hydroxylase
 NCBI Official Symbol    ASPH [Similar Products]
 NCBI Official Synonym Symbols   
AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1
[Similar Products]
 NCBI Protein Information    aspartyl/asparaginyl beta-hydroxylase; A beta H-J-J; ASP beta-hydroxylase; aspartyl/asparaginyl-beta-hydroxylase; cardiac junctin; humbug; junctate; peptide-aspartate beta-dioxygenase
 UniProt Protein Name    Aspartyl/asparaginyl beta-hydroxylase
 UniProt Synonym Protein Names   
Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase
 Protein Family    Aspartyl/asparaginyl beta-hydroxylase
 UniProt Gene Name    ASPH [Similar Products]
 UniProt Synonym Gene Names    BAH; ASP beta-hydroxylase [Similar Products]
 UniProt Entry Name    ASPH_HUMAN
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 NCBI Summary for ASPH    This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
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 UniProt Comments for ASPH    ASPH: Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Belongs to the aspartyl/asparaginyl beta-hydroxylase family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Membrane protein, integral; EC 1.14.11.16

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; endoplasmic reticulum; integral to membrane; plasma membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; electron carrier activity; structural constituent of muscle; calcium ion binding; structural molecule activity; peptide-aspartate beta-dioxygenase activity

Biological Process: peptidyl-aspartic acid hydroxylation; negative regulation of cell proliferation; activation of store-operated calcium channel activity; muscle contraction; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; regulation of protein stability; regulation of inositol-1,4,5-triphosphate receptor activity; palate development; detection of calcium ion; pattern specification process; limb morphogenesis; response to ATP
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 Research Articles on ASPH    1. this study provides evidence that ASPH is mutated in a distinct form of syndromic ectopia lentis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ASPH recombinant proteinDiseases associated with ASPH recombinant protein
 Reference Product  PubMed Publications
 RYR2 recombinant protein  >24 publications with ASPH and RYR2
 TRDN recombinant protein  >13 publications with ASPH and TRDN
 CASQ2 recombinant protein  >8 publications with ASPH and CASQ2
 INS recombinant protein  >1 publications with ASPH and INS
 CASQ1 recombinant protein  >1 publications with ASPH and CASQ1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >23 publications with ASPH and Cardiovascular Diseases
 Heart Diseases Antibodies  >21 publications with ASPH and Heart Diseases
 Hypertrophy Antibodies  >10 publications with ASPH and Hypertrophy
 Heart Failure Antibodies  >9 publications with ASPH and Heart Failure
 Disease Models, Animal Antibodies  >7 publications with ASPH and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with ASPH and Nervous System Diseases
 Cardiomegaly Antibodies  >6 publications with ASPH and Cardiomegaly
 Carcinoma, Hepatocellular Antibodies  >5 publications with ASPH and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with ASPH and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with ASPH and Liver Diseases
Organs/Tissues associated with ASPH recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >67 publications with ASPH and Muscle
 Heart Antibodies  >43 publications with ASPH and Heart
 Liver Antibodies  >10 publications with ASPH and Liver
 Thymus Antibodies  >5 publications with ASPH and Thymus
 Kidney Antibodies  >5 publications with ASPH and Kidney
 Embryonic Tissue Antibodies  >4 publications with ASPH and Embryonic Tissue
 Lung Antibodies  >4 publications with ASPH and Lung
 Brain Antibodies  >4 publications with ASPH and Brain
 Eye Antibodies  >3 publications with ASPH and Eye
 Spleen Antibodies  >3 publications with ASPH and Spleen
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