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ATOH1 recombinant protein :: Atonal Homolog 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145153 ATOH1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Atonal Homolog 1 (ATOH1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Atonal Homolog 1

 Product Synonym Names    ATOH1 Human; Atonal Homolog 1 Human Recombinant; Atonal homolog 1 (Drosophila); Helix-loop-helix protein hATH-1; Class A basic helix-loop-helix protein 14; bHLHa14; HATH1; Math1
 Product Gene Name   

ATOH1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MKQRRLAANA RERRRMHGLN HAFDQLRNVI PSFNNDKKLS KYETLQMAQI YINALSELLQ TPSGGEQPPP PPASCKSDHH HLRTAASYEG GAGNATAAGA QQASGGSQRP TPPGSCRTRF SAPASAGGYS VQLDALHFST FEDSALTAMM AQKNLSPSLP GSILQPVQEE NSKTSPRSHR SDGEFSPHSH YSDSDEAS
 OMIM    601461
 3D Structure    ModBase 3D Structure for Q92858
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 Host    E Coli
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE.
 Form/Format    The ATOH1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA and BSA).
Avoid multiple freeze-thaw cycels.
 Other Notes    Small volumes of ATOH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ATOH1 recombinant protein

   Description: ATOH1 Human Recombinant produced in E Coli is a single polypeptide chain containing 198 amino acids (158-354) and having a molecular mass of 21.3kDa.ATOH1 is purified by proprietary chromatographic techniques.

Introduction: ATOH1 activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is entirely provoked by the negative regulator of neurogenesis HES1. ATOH1 takes part in the differentiation of divisions of neural cells by activating E box-dependent transcription.
 Product Categories/Family for ATOH1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for ATOH1. It may not necessarily be applicable to this product.
 NCBI GI #    4885075
 NCBI GeneID    474
 NCBI Accession #    NP_005163.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005172.1 [Other Products]
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 UniProt Primary Accession #    Q92858 [Other Products]
 UniProt Secondary Accession #    Q14CT9 [Other Products]
 UniProt Related Accession #    Q92858 [Other Products]
 Molecular Weight    38,160 Da
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 NCBI Official Full Name    protein atonal homolog 1
 NCBI Official Synonym Full Names    atonal homolog 1 (Drosophila)
 NCBI Official Symbol    ATOH1 [Similar Products]
 NCBI Official Synonym Symbols   
ATH1; HATH1; MATH-1; bHLHa14
[Similar Products]
 NCBI Protein Information    protein atonal homolog 1; class A basic helix-loop-helix protein 14; helix-loop-helix protein hATH-1
 UniProt Protein Name    Protein atonal homolog 1
 UniProt Synonym Protein Names   
Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1
 Protein Family    Protein atonal
 UniProt Gene Name    ATOH1 [Similar Products]
 UniProt Synonym Gene Names    ATH1; BHLHA14; bHLHa14; hATH1 [Similar Products]
 UniProt Entry Name    ATOH1_HUMAN
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 NCBI Summary for ATOH1    This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ATOH1    ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: nucleus

Molecular Function: protein dimerization activity; chromatin DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; central nervous system development; auditory receptor cell fate determination; neuron migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of apoptosis
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 Research Articles on ATOH1    1. Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATOH1 recombinant proteinDiseases associated with ATOH1 recombinant protein
 Reference Product  PubMed Publications
 SOX2 recombinant protein  >28 publications with ATOH1 and SOX2
 PROX1 recombinant protein  >7 publications with ATOH1 and PROX1
 HIC1 recombinant protein  >5 publications with ATOH1 and HIC1
 TCF4 recombinant protein  >3 publications with ATOH1 and TCF4
 MUC6 recombinant protein  >2 publications with ATOH1 and MUC6
 ZIC1 recombinant protein  >2 publications with ATOH1 and ZIC1
 HES6 recombinant protein  >2 publications with ATOH1 and HES6
 POU4F1 recombinant protein  >1 publications with ATOH1 and POU4F1
 Disease Name  Pubmed Publications
 Medulloblastoma Antibodies  >33 publications with ATOH1 and Medulloblastoma
 Brain Diseases Antibodies  >20 publications with ATOH1 and Brain Diseases
 Inflammation Antibodies  >8 publications with ATOH1 and Inflammation
 Colitis Antibodies  >7 publications with ATOH1 and Colitis
 Hyperplasia Antibodies  >5 publications with ATOH1 and Hyperplasia
 Necrosis Antibodies  >5 publications with ATOH1 and Necrosis
 Ataxia Antibodies  >4 publications with ATOH1 and Ataxia
 Lung Diseases Antibodies  >2 publications with ATOH1 and Lung Diseases
 Intracranial Hypertension Antibodies  >1 publications with ATOH1 and Intracranial Hypertension
 Hypertrophy Antibodies  >1 publications with ATOH1 and Hypertrophy
Organs/Tissues associated with ATOH1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with ATOH1 and Mixed
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