NP_005163.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54.2 kDa
NCBI Official Full Name
protein atonal homolog 1
NCBI Official Synonym Full Names
atonal bHLH transcription factor 1
NCBI Protein Information
protein atonal homolog 1
UniProt Protein Name
Protein atonal homolog 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1
UniProt Synonym Gene Names
UniProt Entry Name
ATOH1_HUMAN
NCBI Summary for ATOH1
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
UniProt Comments for ATOH1
ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.
Protein type: DNA-binding; Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: nucleus
Molecular Function: chromatin DNA binding; protein dimerization activity; transcription factor activity
Biological Process: auditory receptor cell fate determination; auditory receptor cell fate specification; axon guidance; central nervous system development; cerebral cortex development; inner ear morphogenesis; negative regulation of apoptosis; neuron migration; Notch signaling pathway; positive regulation of auditory receptor cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Product References and Citations for ATOH1 recombinant protein
Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.Hum. Mol. Genet. 5:1207-1216(1996)
Research Articles on ATOH1
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Products associated with ATOH1 recombinant protein
Diseases associated with ATOH1 recombinant protein
Organs/Tissues associated with ATOH1 recombinant protein
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