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Npr1 recombinant protein :: Atrial natriuretic peptide receptor 1 (Npr1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS965263 Npr1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,220 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,440 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,975 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,975 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,440 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,440 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Atrial natriuretic peptide receptor 1 (Npr1), Recombinant Protein

 Also Known As   

Recombinant Mouse Atrial natriuretic peptide receptor 1 (Npr1)

 Product Synonym Names    Atrial natriuretic peptide receptor 1; EC=4.6.1.2; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
 Product Gene Name   

Npr1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Npr1; Npra [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    29-469
 Sequence    SD LTVAVVLPLT NTSYPWSWAR VGPAVELALG RVKARPDLLP GWTVRMVLGS SENAAGVCSD TAAPLAAVDL KWEHSPAVFL GPGCVYSAAP VGRFTAHWRV PLLTAGAPAL GIGVKDEYAL TTRTGPSHVK LGDFVTALHR RLGWEHQALV LYADRLGDDR PCFFIVEGLY MRVRERLNIT VNHQEFVEGD PDHYTKLLRT VQRKGRVIYI CSSPDAFRNL MLLALDAGLT GEDYVFFHLD VFGQSLQGAQ GPVPRKPWER DDGQDRRARQ AFQAAKIITY KEPDNPEYLE FLKQLKLLAD KKFNFTMEDG LKNIIPASFH DGLLLYVQAV TETLAQGGTV TDGENITQRM WNRSFQGVTG YLKIDRNGDR DTDFSLWDMD PETGAFRVVL NFNGTSQELM AVSEHRLYWP LGYPPPDIPK CGFDNEDPAC NQDHFSTLE
 3D Structure    ModBase 3D Structure for P18293
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Npr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Npr1. It may not necessarily be applicable to this product.
 NCBI GI #    113930718
 NCBI GeneID    18160
 NCBI Accession #    NP_032753.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_008727.5 [Other Products]
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 UniProt Primary Accession #    P18293 [Other Products]
 UniProt Related Accession #    P18293 [Other Products]
 Molecular Weight    119,109 Da
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 NCBI Official Full Name    atrial natriuretic peptide receptor 1
 NCBI Official Synonym Full Names    natriuretic peptide receptor 1
 NCBI Official Symbol    Npr1 [Similar Products]
 NCBI Official Synonym Symbols   
GC-A; NPRA; Pndr; NPR-A; AI893888
[Similar Products]
 NCBI Protein Information    atrial natriuretic peptide receptor 1; ANP-A; ANPR-A; Nppa receptor; guanylyl cyclase-A; guanylate cyclase A; atrial natriuretic peptide receptor type A
 UniProt Protein Name    Atrial natriuretic peptide receptor 1
 UniProt Synonym Protein Names   
Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
 Protein Family    Atrial natriuretic peptide receptor
 UniProt Gene Name    Npr1 [Similar Products]
 UniProt Synonym Gene Names    Npra; ANP-A; ANPR-A; NPR-A; GC-A [Similar Products]
 UniProt Entry Name    ANPRA_MOUSE
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 UniProt Comments for Npr1    ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.

Protein type: EC 4.6.1.2; Protein kinase, dual-specificity (receptor); Receptor, misc.; Lyase; Nucleotide Metabolism - purine; Protein kinase, RGC; Kinase, protein; Guanylyl cyclase; Membrane protein, integral; RGC group; RGC family

Cellular Component: membrane; plasma membrane; integral to membrane; intracellular; receptor complex

Molecular Function: guanylate cyclase activity; GTP binding; phosphorus-oxygen lyase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; transferase activity, transferring phosphorus-containing groups; lyase activity; nucleotide binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: cGMP biosynthetic process; cyclic nucleotide biosynthetic process; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; negative regulation of smooth muscle cell proliferation; regulation of blood pressure; receptor guanylyl cyclase signaling pathway; regulation of blood vessel size; dopamine metabolic process; protein amino acid phosphorylation
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 Research Articles on Npr1    1. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Npr1 recombinant proteinDiseases associated with Npr1 recombinant protein
 Products by Pathway  Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >23 publications with Npr1 and Hypertension
 Hypertrophy Antibodies  >21 publications with Npr1 and Hypertrophy
 Heart Diseases Antibodies  >19 publications with Npr1 and Heart Diseases
 Necrosis Antibodies  >15 publications with Npr1 and Necrosis
 Fibrosis Antibodies  >14 publications with Npr1 and Fibrosis
 Cardiomegaly Antibodies  >13 publications with Npr1 and Cardiomegaly
 Heart Failure Antibodies  >9 publications with Npr1 and Heart Failure
 Inflammation Antibodies  >7 publications with Npr1 and Inflammation
 Gastrointestinal Diseases Antibodies  >5 publications with Npr1 and Gastrointestinal Diseases
 Brain Diseases Antibodies  >3 publications with Npr1 and Brain Diseases
Organs/Tissues associated with Npr1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with Npr1 and Brain
 Kidney Antibodies  >18 publications with Npr1 and Kidney
 Embryonic Tissue Antibodies  >4 publications with Npr1 and Embryonic Tissue
 Adrenal Gland Antibodies  >3 publications with Npr1 and Adrenal Gland
 Lung Antibodies  >3 publications with Npr1 and Lung
 Liver Antibodies  >2 publications with Npr1 and Liver
 Salivary Gland Antibodies  >1 publications with Npr1 and Salivary Gland
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