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AURKA recombinant protein :: Aurora kinase A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203344
SDS-PAGE
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aurora kinase A (AURKA), Recombinant Protein

 Also Known As   

Aurora kinase A, 1-403aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    Serine/threonine-protein kinase 6; Aurora-A; AIK; ARK1; AuRA; BTAK; STK15; STK6; Aurora kinase A; AuRKA; Serine/threonine-protein kinase 6 Aurora 2; Aurora A; aurora kinase A; IAK; Serine/threonine kinase 15.
 Product Gene Name   

AURKA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 0.5mM DTT, 100mM NaCl, 0.1mM EDTA, 0.1mM EGTA, 0.1mM PMSF, 20% glycerol.
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of AURKA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AURKA recombinant protein

   Aurora Kinase A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora kinase A is highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also this protein plays a crucial role in tumourigenesis and is overexpressed in many kinds of cancers. Recombinant human Aurora-A fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for AURKA recombinant protein    Cell Cycle
 Applications Tested/Suitable for AURKA recombinant protein   

SDS-PAGE

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 SDS-PAGE of AURKA recombinant protein    AURKA recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for AURKA. It may not necessarily be applicable to this product.
 NCBI GI #    38327562
 NCBI GeneID    6790
 NCBI Accession #    NP_003591 [Other Products]
 NCBI GenBank Nucleotide #    NM_003600.2 [Other Products]
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 UniProt Secondary Accession #    O60445; O75873; Q9BQD6; Q9UPG5; E1P5F9 [Other Products]
 UniProt Related Accession #    O14965 [Other Products]
 Molecular Weight    47.9 kDa (423aa) [Similar Products]
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 NCBI Official Full Name    aurora kinase A
 NCBI Official Synonym Full Names    aurora kinase A
 NCBI Official Symbol    AURKA [Similar Products]
 NCBI Official Synonym Symbols   
AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47
[Similar Products]
 NCBI Protein Information    aurora kinase A; ARK-1; Aurora-A kinase; IPL1-related kinase; aurora 2; aurora-related kinase 1; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; hARK1; protein phosphatase 1, regulatory subunit 47; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A
 UniProt Protein Name    Aurora kinase A
 UniProt Synonym Protein Names   
Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A
 Protein Family    Aurora kinase
 UniProt Gene Name    AURKA [Similar Products]
 UniProt Synonym Gene Names    AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1 [Similar Products]
 UniProt Entry Name    AURKA_HUMAN
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 NCBI Summary for AURKA    The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AURKA    AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Oncoprotein; EC 2.7.11.1; Kinase, protein; Other group; AUR family

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: germinal vesicle; centrosome; pronucleus; spindle pole centrosome; cytosol; microtubule cytoskeleton; axon hillock; perinuclear region of cytoplasm; spindle microtubule; spindle; midbody; spindle midzone; nucleus; condensed nuclear chromosome, pericentric region

Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: spindle stabilization; mitosis; regulation of centrosome cycle; positive regulation of mitosis; protein amino acid autophosphorylation; regulation of protein stability; regulation of cytokinesis; protein amino acid phosphorylation; mitotic spindle organization and biogenesis; mitotic centrosome separation; centrosome localization; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; negative regulation of protein binding; G2/M transition of mitotic cell cycle; spindle assembly involved in female meiosis I; anterior/posterior axis specification; negative regulation of apoptosis

Disease: Colorectal Cancer
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Product References and Citations for AURKA recombinant protein

   Tchatchou S., et al. (2007). Cancer lett. 247(2): 266-72
Chen SS., et al. (2002). EMBO J. 21(17): 4491-9
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 Research Articles on AURKA    1. we demonstrate that ectopic expression of Aurora A and JAK2 together is more effective than each alone at inducing non-transformed cells to grow in an anchorage-independent manner and to invade
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AURKA recombinant proteinPathways associated with AURKA recombinant protein
 Reference Product  PubMed Publications
 PLK1 recombinant protein  >43 publications with AURKA and PLK1
 TP53 recombinant protein  >28 publications with AURKA and TP53
 TPX2 recombinant protein  >27 publications with AURKA and TPX2
 BIRC5 recombinant protein  >24 publications with AURKA and BIRC5
 CDC20 recombinant protein  >12 publications with AURKA and CDC20
 TACC3 recombinant protein  >10 publications with AURKA and TACC3
 PTTG1 recombinant protein  >5 publications with AURKA and PTTG1
 UBE2C recombinant protein  >3 publications with AURKA and UBE2C
 DLGAP5 recombinant protein  >2 publications with AURKA and DLGAP5
 C13orf34 recombinant protein  >1 publications with AURKA and C13orf34
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
Diseases associated with AURKA recombinant proteinOrgans/Tissues associated with AURKA recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >168 publications with AURKA and Carcinoma
 Breast Neoplasms Antibodies  >98 publications with AURKA and Breast Neoplasms
 Adenocarcinoma Antibodies  >74 publications with AURKA and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >57 publications with AURKA and Cell Transformation, Neoplastic
 Colorectal Neoplasms Antibodies  >53 publications with AURKA and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >52 publications with AURKA and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >37 publications with AURKA and Carcinoma, Squamous Cell
 Ovarian Neoplasms Antibodies  >31 publications with AURKA and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >30 publications with AURKA and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >29 publications with AURKA and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with AURKA and Blood
 Lung Antibodies  >40 publications with AURKA and Lung
 Prostate Antibodies  >35 publications with AURKA and Prostate
 Liver Antibodies  >28 publications with AURKA and Liver
 Bone Antibodies  >23 publications with AURKA and Bone
 Kidney Antibodies  >21 publications with AURKA and Kidney
 Skin Antibodies  >20 publications with AURKA and Skin
 Bladder Antibodies  >18 publications with AURKA and Bladder
 Brain Antibodies  >16 publications with AURKA and Brain
 Ovary Antibodies  >13 publications with AURKA and Ovary
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