NP_001028842.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
bcl-2-like protein 1 isoform 2
NCBI Official Synonym Full Names
Bcl2-like 1
NCBI Protein Information
bcl-2-like protein 1; bcl2-L-1; B cell lymphoma 2 like; B cell lymphoma like X; apoptosis regulator Bcl-X
UniProt Protein Name
Bcl-2-like protein 1
UniProt Synonym Protein Names
Apoptosis regulator Bcl-X
UniProt Synonym Gene Names
UniProt Entry Name
B2CL1_RAT
NCBI Summary for Bcl2L
inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury [RGD, Feb 2006]
UniProt Comments for Bcl2L
Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Autophagy; Apoptosis; Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrial envelope; centrosome; nuclear membrane; synaptic vesicle membrane; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; mitochondrial inner membrane; mitochondrial membrane; cytoplasm; nucleolus; intracellular; nucleus; cell junction
Molecular Function: BH domain binding; identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; caspase inhibitor activity; BH3 domain binding; protein kinase binding
Biological Process: response to peptide hormone stimulus; apoptosis; positive regulation of apoptosis; negative regulation of caspase activity; cellular process regulating host cell cycle in response to virus; response to organic cyclic substance; germ cell development; regulation of apoptosis; response to radiation; regulation of mitochondrial membrane potential; ovarian follicle development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; response to electrical stimulus; release of cytochrome c from mitochondria; response to inorganic substance; in utero embryonic development; response to virus; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; endocytosis; response to organic nitrogen; cell proliferation; neuron apoptosis; fertilization; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; response to lead ion; response to hypoxia; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; response to oxidative stress; negative regulation of apoptosis; growth
Research Articles on Bcl2L
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Pathways associated with Bcl2L recombinant protein
Diseases associated with Bcl2L recombinant protein
Organs/Tissues associated with Bcl2L recombinant protein
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