NP_001182.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
bcl-2-like protein 1 isoform 2
NCBI Official Synonym Full Names
BCL2-like 1
NCBI Official Synonym Symbols
BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S [Similar Products]
NCBI Protein Information
bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52
UniProt Protein Name
Bcl-2-like protein 1
UniProt Synonym Protein Names
Apoptosis regulator Bcl-X
UniProt Synonym Gene Names
UniProt Entry Name
B2CL1_HUMAN
NCBI Summary for Bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
UniProt Comments for Bcl2L
Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Autophagy; Membrane protein, integral; Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: centrosome; nuclear membrane; synaptic vesicle membrane; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; nucleus; cell junction
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding
Biological Process: negative regulation of autophagy; apoptosis; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; apoptotic mitochondrial changes; regulation of mitochondrial membrane potential; ovarian follicle development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; mitotic cell cycle checkpoint; male gonad development; suppression by virus of host apoptosis; endocytosis; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; innate immune response; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; negative regulation of apoptosis; growth
Research Articles on Bcl2L
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Products associated with Bcl2L recombinant protein
Pathways associated with Bcl2L recombinant protein
Diseases associated with Bcl2L recombinant protein
Organs/Tissues associated with Bcl2L recombinant protein
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