NP_033871.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
apoptosis regulator Bcl-2 isoform 1
NCBI Official Synonym Full Names
B cell leukemia/lymphoma 2
NCBI Official Synonym Symbols
Bcl-2; AW986256; C430015F12Rik; D630044D05Rik; D830018M01Rik [Similar Products]
NCBI Protein Information
apoptosis regulator Bcl-2; B-cell leukemia/lymphoma 2
UniProt Protein Name
Apoptosis regulator Bcl-2
UniProt Synonym Gene Names
UniProt Entry Name
BCL2_MOUSE
UniProt Comments for Bcl2
Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.
Protein type: Autophagy; Apoptosis; Oncoprotein; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; mitochondrion; cell; endoplasmic reticulum; integral to membrane; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus; myelin sheath
Molecular Function: identical protein binding; BH domain binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; channel activity; channel inhibitor activity; transcription factor binding; protein phosphatase binding; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding; BH3 domain binding
Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; regulation of cell cycle; response to toxin; ear development; B cell receptor signaling pathway; negative regulation of myeloid cell apoptosis; regulation of protein localization; negative regulation of ossification; regulation of transmembrane transporter activity; negative regulation of neuron apoptosis; kidney development; T cell differentiation; response to drug; spleen development; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of gene expression; negative regulation of osteoblast proliferation; response to oxidative stress; lymphocyte homeostasis; negative regulation of apoptosis; negative regulation of autophagy; positive regulation of pigmentation; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; positive regulation of skeletal muscle fiber development; ureteric bud development; positive regulation of cell proliferation; regulation of viral genome replication; negative regulation of cell migration; transmembrane transport; mesenchymal cell development; leukocyte homeostasis; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; response to UV-B; cell proliferation; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; pigmentation; ureteric bud branching; homeostasis of number of cells within a tissue; negative regulation of cell growth; response to acid; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; post-embryonic development; cochlear nucleus development; regulation of apoptosis; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; positive regulation of B cell proliferation; T cell homeostasis; negative regulation of mitotic cell cycle; cell growth; defense response to virus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; induction of apoptosis via death domain receptors; response to steroid hormone stimulus; B cell differentiation; gland morphogenesis; regulation of pigmentation during development; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; regulation of cell-matrix adhesion; apoptosis; negative regulation of retinal cell programmed cell death; pigmentation during development; cell morphogenesis; regulation of protein stability; protein amino acid dephosphorylation; apoptotic mitochondrial changes; B cell homeostasis; ovarian follicle development; regulation of catalytic activity; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; hemopoiesis; response to iron ion; negative regulation of cellular pH reduction; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; regulation of programmed cell death; cellular calcium ion homeostasis; immune system development; T cell lineage commitment; neuron apoptosis; response to hydrogen peroxide; axonogenesis; response to cytokine stimulus; response to DNA damage stimulus; induction of apoptosis by oxidative stress; growth
Research Articles on Bcl2
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Pathways associated with Bcl2 recombinant protein
Diseases associated with Bcl2 recombinant protein
Disease Name |
Pubmed Publications |
Lymphoma, Non-Hodgkin Antibodies |
>657 publications with Bcl2 and Lymphoma, Non-Hodgkin |
Carcinoma Antibodies |
>586 publications with Bcl2 and Carcinoma |
Lymphoma, Follicular Antibodies |
>348 publications with Bcl2 and Lymphoma, Follicular |
Necrosis Antibodies |
>340 publications with Bcl2 and Necrosis |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>321 publications with Bcl2 and Lymphoma, Large B-Cell, Diffuse |
Breast Neoplasms Antibodies |
>283 publications with Bcl2 and Breast Neoplasms |
Adenocarcinoma Antibodies |
>230 publications with Bcl2 and Adenocarcinoma |
Disease Progression Antibodies |
>212 publications with Bcl2 and Disease Progression |
Inflammation Antibodies |
>151 publications with Bcl2 and Inflammation |
Cell Transformation, Neoplastic Antibodies |
>132 publications with Bcl2 and Cell Transformation, Neoplastic |
Organs/Tissues associated with Bcl2 recombinant protein
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