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Bcl-2 recombinant protein :: B-Cell Leukemia/Lymphoma 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143396 Bcl-2 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,665 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Cell Leukemia/Lymphoma 2 (Bcl-2), Recombinant Protein

 Also Known As   

Recombinant Human B-Cell Leukemia/Lymphoma 2, (1-206 a.a.)

 Product Synonym Names    Bcl 2 Human (1-206 a.a.); B-Cell Leukemia/Lymphoma 2, (1-206 a.a.) Human Recombinant; Apoptosis regulator Bcl-2; BCL2; B-cell CLL/lymphoma 2; Bcl-2; Bcl-2 (1-206 a.a.)
 Product Gene Name   

Bcl-2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151430
 3D Structure    ModBase 3D Structure for P10415
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    Suspend Bcl-2 in 100ul of 0.5M Acetic acid, over night at 4 degree C. Dilute 10 fold into selected buffer system. BCL-2 has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.
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 Preparation and Storage    Lyophilized Bcl-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Bcl-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of Bcl-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Bcl-2 recombinant protein

   Description: Bcl-2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-206. The wild type Bcl-2 is missing 12 amino acids from C-terminus. C-terminus is fused to His-Tag. C-terminus his-tag, mimics the deleted C-terminus membrane domain thus maintaining its biological activity. Bcl-2 is purified by proprietary chromatographic techniques.

Introduction: BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
 Product Categories/Family for Bcl-2 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; B Cell Lymphoma
NCBI/Uniprot data below describe general gene information for Bcl-2. It may not necessarily be applicable to this product.
 NCBI GI #    72198189
 NCBI GeneID    596
 NCBI Accession #    NP_000624.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000633.2 [Other Products]
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 UniProt Primary Accession #    P10415 [Other Products]
 UniProt Secondary Accession #    P10416; Q13842; Q16197; C9JHD5 [Other Products]
 UniProt Related Accession #    P10415 [Other Products]
 Molecular Weight    22,337 Da
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 NCBI Official Full Name    apoptosis regulator Bcl-2 alpha isoform
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 2
 NCBI Official Symbol    BCL2 [Similar Products]
 NCBI Official Synonym Symbols   
Bcl-2; PPP1R50
[Similar Products]
 NCBI Protein Information    apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50
 UniProt Protein Name    Apoptosis regulator Bcl-2
 UniProt Gene Name    BCL2 [Similar Products]
 UniProt Entry Name    BCL2_HUMAN
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 NCBI Summary for Bcl-2    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bcl-2    Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Membrane protein, integral; Autophagy; Oncoprotein; Apoptosis

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: pore complex; endoplasmic reticulum membrane; mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; protein heterodimerization activity; channel activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding

Biological Process: positive regulation of catalytic activity; response to nicotine; focal adhesion formation; developmental growth; renal system process; pigment granule organization and biogenesis; protein polyubiquitination; response to toxin; response to glucocorticoid stimulus; T cell differentiation in the thymus; ear development; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; female pregnancy; glomerulus development; negative regulation of mitochondrial depolarization; post-embryonic development; cochlear nucleus development; cellular response to glucose starvation; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of mitochondrial membrane potential; positive regulation of B cell proliferation; negative regulation of ossification; regulation of transmembrane transporter activity; T cell homeostasis; negative regulation of neuron apoptosis; cell growth; defense response to virus; spleen development; response to drug; positive regulation of neuron maturation; release of cytochrome c from mitochondria; axon regeneration; regulation of protein homodimerization activity; cell aging; actin filament organization; digestive tract morphogenesis; regulation of calcium ion transport; positive regulation of cell growth; organ growth; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of osteoblast proliferation; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; negative regulation of apoptosis; B cell proliferation; negative regulation of autophagy; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; negative regulation of retinal cell programmed cell death; apoptosis; regulation of cell-matrix adhesion; regulation of protein stability; protein amino acid dephosphorylation; positive regulation of smooth muscle cell migration; response to radiation; positive regulation of skeletal muscle fiber development; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; response to iron ion; regulation of viral genome replication; negative regulation of cell migration; transmembrane transport; negative regulation of cellular pH reduction; mesenchymal cell development; ossification; hair follicle morphogenesis; CD8-positive, alpha-beta T cell lineage commitment; thymus development; B cell lineage commitment; male gonad development; peptidyl-threonine phosphorylation; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; peptidyl-serine phosphorylation; endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; axonogenesis; response to hydrogen peroxide; homeostasis of number of cells within a tissue; ureteric bud branching; response to cytokine stimulus; innate immune response; negative regulation of cell growth; response to DNA damage stimulus; induction of apoptosis by oxidative stress
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 Research Articles on Bcl-2    1. Decreased miR-34a expression and increased FOXP1, p53, and BCL2 coexpression predict poor overall survival for MALT lymphoma and diffuse large B-cell lymphoma patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bcl-2 recombinant proteinPathways associated with Bcl-2 recombinant protein
 Reference Product  PubMed Publications
 BAX recombinant protein  >1446 publications with Bcl-2 and BAX
 BAD recombinant protein  >218 publications with Bcl-2 and BAD
 TP53 recombinant protein  >146 publications with Bcl-2 and TP53
 BID recombinant protein  >109 publications with Bcl-2 and BID
 BAK1 recombinant protein  >75 publications with Bcl-2 and BAK1
 BECN1 recombinant protein  >50 publications with Bcl-2 and BECN1
 BIK recombinant protein  >31 publications with Bcl-2 and BIK
 BBC3 recombinant protein  >21 publications with Bcl-2 and BBC3
 BCL2L11 recombinant protein  >17 publications with Bcl-2 and BCL2L11
 FKBP8 recombinant protein  >1 publications with Bcl-2 and FKBP8
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with Bcl-2 recombinant proteinOrgans/Tissues associated with Bcl-2 recombinant protein
 Disease Name  Pubmed Publications
 Lymphoma, Non-Hodgkin Antibodies  >759 publications with Bcl-2 and Lymphoma, Non-Hodgkin
 Carcinoma Antibodies  >678 publications with Bcl-2 and Carcinoma
 Lymphoma, Follicular Antibodies  >393 publications with Bcl-2 and Lymphoma, Follicular
 Necrosis Antibodies  >380 publications with Bcl-2 and Necrosis
 Lymphoma, Large B-Cell, Diffuse Antibodies  >378 publications with Bcl-2 and Lymphoma, Large B-Cell, Diffuse
 Breast Neoplasms Antibodies  >315 publications with Bcl-2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >273 publications with Bcl-2 and Adenocarcinoma
 Disease Progression Antibodies  >256 publications with Bcl-2 and Disease Progression
 Inflammation Antibodies  >201 publications with Bcl-2 and Inflammation
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >152 publications with Bcl-2 and Leukemia, Lymphocytic, Chronic, B-Cell
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1004 publications with Bcl-2 and Blood
 Brain Antibodies  >369 publications with Bcl-2 and Brain
 Bone Antibodies  >353 publications with Bcl-2 and Bone
 Muscle Antibodies  >294 publications with Bcl-2 and Muscle
 Lung Antibodies  >271 publications with Bcl-2 and Lung
 Lymph Node Antibodies  >264 publications with Bcl-2 and Lymph Node
 Bone Marrow Antibodies  >248 publications with Bcl-2 and Bone Marrow
 Vascular Antibodies  >225 publications with Bcl-2 and Vascular
 Lymph Antibodies  >212 publications with Bcl-2 and Lymph
 Heart Antibodies  >212 publications with Bcl-2 and Heart
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