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LAB7-2 recombinant protein :: B-Lymphocyte Activation Antigen B7-2 (LAB7-2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018368 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $270 +1 FREE 8GB USB
0.1 mg  /  $425 +1 FREE 8GB USB
0.2 mg  /  $520 +1 FREE 8GB USB
0.5 mg  /  $1,005 +1 FREE 8GB USB
1 mg  /  $1,500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Lymphocyte Activation Antigen B7-2 (LAB7-2), Recombinant Protein

 Also Known As   

Recombinant B-Lymphocyte Activation Antigen B7-2 (LAB7-2)

 Product Gene Name   

LAB7-2 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: B-Lymphocyte Activation Antigen B7-2 (LAB7-2) (MBS2013014)
Antigen: B-Lymphocyte Activation Antigen B7-2 (LAB7-2) (MBS2018368)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- QNQSL SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KC
 Chromosome Location    Chromosome: 3; NC_000003.11 (121774209..121839990). Location: 3q21
 OMIM    601020
 3D Structure    ModBase 3D Structure for P42081
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Gln46~Cys282 (Accession # P42081) with two N-terminal Tags, His-tag and T7-tag
 Subcellular Location    Cell membrane; Single-pass type I membrane protein
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    8.2
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of LAB7-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LAB7-2 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for LAB7-2 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of LAB7-2 recombinant protein    LAB7-2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for LAB7-2. It may not necessarily be applicable to this product.
 NCBI GI #    332634950
 NCBI GeneID    942
 NCBI Accession #    NP_001193853.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206924.1 [Other Products]
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 UniProt Primary Accession #    P42081 [Other Products]
 UniProt Secondary Accession #    Q13655; Q6FHB1; Q6GTS4; Q7M4L5; A0N0P0; B7Z2F3; B7Z702; E7ETN5; E9PC27 [Other Products]
 UniProt Related Accession #    P42081 [Other Products]
 Molecular Weight    30.9kDa
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 NCBI Official Full Name    T-lymphocyte activation antigen CD86 isoform 4
 NCBI Official Synonym Full Names    CD86 molecule
 NCBI Official Symbol    CD86 [Similar Products]
 NCBI Official Synonym Symbols   
B70; B7-2; B7.2; LAB72; CD28LG2
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
 UniProt Protein Name    T-lymphocyte activation antigen CD86
 UniProt Synonym Protein Names   
Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1
 UniProt Gene Name    CD86 [Similar Products]
 UniProt Synonym Gene Names    CD28LG2 [Similar Products]
 UniProt Entry Name    CD86_HUMAN
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 NCBI Summary for LAB7-2    This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
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 UniProt Comments for LAB7-2    CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding

Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; negative regulation of T cell anergy; viral reproduction; T cell activation; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; epidermal growth factor receptor signaling pathway; response to drug; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response
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 Research Articles on LAB7-2    1. Our results indicate that the methylation pattern in the CD86 promoter and CpG island is closely related to the expression of this co-stimulatory molecule in keratinocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LAB7-2 recombinant proteinPathways associated with LAB7-2 recombinant protein
 Reference Product  PubMed Publications
 CD80 recombinant protein  >4476 publications with LAB7-2 and CD80
 CD40 recombinant protein  >2204 publications with LAB7-2 and CD40
 CD4 recombinant protein  >1688 publications with LAB7-2 and CD4
 CD28 recombinant protein  >1051 publications with LAB7-2 and CD28
 CTLA4 recombinant protein  >633 publications with LAB7-2 and CTLA4
 TLR2 recombinant protein  >192 publications with LAB7-2 and TLR2
 TLR9 recombinant protein  >113 publications with LAB7-2 and TLR9
 CD40LG recombinant protein  >3 publications with LAB7-2 and CD40LG
 IFNG recombinant protein  >3 publications with LAB7-2 and IFNG
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
Diseases associated with LAB7-2 recombinant proteinOrgans/Tissues associated with LAB7-2 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1086 publications with LAB7-2 and Necrosis
 Neoplasms Antibodies  >1071 publications with LAB7-2 and Neoplasms
 Inflammation Antibodies  >728 publications with LAB7-2 and Inflammation
 Nervous System Diseases Antibodies  >264 publications with LAB7-2 and Nervous System Diseases
 Lung Diseases Antibodies  >261 publications with LAB7-2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >197 publications with LAB7-2 and Neoplasms, Experimental
 Liver Diseases Antibodies  >176 publications with LAB7-2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >166 publications with LAB7-2 and Cardiovascular Diseases
 Brain Diseases Antibodies  >139 publications with LAB7-2 and Brain Diseases
 Dermatitis, Contact Antibodies  >101 publications with LAB7-2 and Dermatitis, Contact
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5001 publications with LAB7-2 and Blood
 Spleen Antibodies  >645 publications with LAB7-2 and Spleen
 Lymph Node Antibodies  >617 publications with LAB7-2 and Lymph Node
 Lung Antibodies  >328 publications with LAB7-2 and Lung
 Vascular Antibodies  >184 publications with LAB7-2 and Vascular
 Kidney Antibodies  >154 publications with LAB7-2 and Kidney
 Brain Antibodies  >147 publications with LAB7-2 and Brain
 Thymus Antibodies  >115 publications with LAB7-2 and Thymus
 Eye Antibodies  >84 publications with LAB7-2 and Eye
 Pancreas Antibodies  >43 publications with LAB7-2 and Pancreas
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