NP_001193853.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-lymphocyte activation antigen CD86 isoform 4
NCBI Official Synonym Full Names
CD86 molecule
NCBI Official Synonym Symbols
B70; B7-2; B7.2; LAB72; CD28LG2 [Similar Products]
NCBI Protein Information
T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
UniProt Protein Name
T-lymphocyte activation antigen CD86
UniProt Synonym Protein Names
Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1
UniProt Synonym Gene Names
UniProt Entry Name
CD86_HUMAN
NCBI Summary for LAB7-2
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
UniProt Comments for LAB7-2
CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding
Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; negative regulation of T cell anergy; viral reproduction; T cell activation; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; epidermal growth factor receptor signaling pathway; response to drug; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response
Research Articles on LAB7-2
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Products associated with LAB7-2 recombinant protein
Pathways associated with LAB7-2 recombinant protein
Diseases associated with LAB7-2 recombinant protein
Organs/Tissues associated with LAB7-2 recombinant protein
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