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BCA1 recombinant protein :: BCA-1/ BLC Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS140714 BCA1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCA-1/ BLC (BCA1), Recombinant Protein

 Also Known As   

Recombinant Mouse BCA-1/ BLC (CXCL13)

 Product Synonym Names    BCA 1 Mouse; BCA-1/BLC Mouse Recombinant (CXCL13); C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; Cxcl13; Blc; Scyb13
 Product Gene Name   

BCA1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    mBCA1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA
 3D Structure    ModBase 3D Structure for O55038
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by SDS-PAGE.
 Form/Format    The BCA1 protein was lyophilized from a 0.2?m filtered solution in Acetonitrile and TFA.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Biological Activity    The ED50, as measured by its ability to chemoattract human CXCR5-transfected mouse BaF3 cells, is less than 2 ug/ml.
 Solubility    It is recommended to reconstitute the lyophilized CXCL13 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BCA1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of BCA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BCA1 recombinant protein

   Introduction: BCA-1 is a CXC chemokine that is highly expressed in thesecondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt's lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.

Description: CXCL13 Mouse Recombinant (22-109) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10kDa.The BCA-1 is purified by proprietary chromatographic techniques.
 Product Categories/Family for BCA1 recombinant protein    CHEMOKINES
NCBI/Uniprot data below describe general gene information for BCA1. It may not necessarily be applicable to this product.
 NCBI GI #    9256521
 NCBI GeneID    55985
 NCBI Accession #    NP_061354.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018866.2 [Other Products]
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 UniProt Primary Accession #    O55038 [Other Products]
 UniProt Related Accession #    O55038 [Other Products]
 Molecular Weight    11,927 Da
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 NCBI Official Full Name    C-X-C motif chemokine 13
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 13
 NCBI Official Symbol    Cxcl13 [Similar Products]
 NCBI Official Synonym Symbols   
BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 13
 UniProt Protein Name    C-X-C motif chemokine 13
 UniProt Synonym Protein Names   
B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
 UniProt Gene Name    Cxcl13 [Similar Products]
 UniProt Synonym Gene Names    Blc; Scyb13 [Similar Products]
 UniProt Entry Name    CXL13_MOUSE
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 UniProt Comments for BCA1    CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR10 chemokine receptor binding; chemokine activity; CXCR3 chemokine receptor binding; CXCR5 chemokine receptor binding; fibroblast growth factor binding; heparin binding; protein heterodimerization activity; receptor agonist activity

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; defense response to bacterium; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lymph node development; lymphocyte chemotaxis across high endothelial venule; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; positive regulation of leukocyte chemotaxis; regulation of cell proliferation; response to lipopolysaccharide
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BCA1 recombinant proteinPathways associated with BCA1 recombinant protein
 Reference Product  PubMed Publications
 Cxcr5 recombinant protein  >229 publications with BCA1 and Cxcr5
 Cxcl10 recombinant protein  >72 publications with BCA1 and Cxcl10
 Ccr7 recombinant protein  >59 publications with BCA1 and Ccr7
 Cxcl9 recombinant protein  >40 publications with BCA1 and Cxcl9
 Ccl5 recombinant protein  >35 publications with BCA1 and Ccl5
 Cxcr3 recombinant protein  >32 publications with BCA1 and Cxcr3
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with BCA1 recombinant proteinOrgans/Tissues associated with BCA1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >191 publications with BCA1 and Inflammation
 Necrosis Antibodies  >69 publications with BCA1 and Necrosis
 Disease Models, Animal Antibodies  >61 publications with BCA1 and Disease Models, Animal
 Carcinoma Antibodies  >36 publications with BCA1 and Carcinoma
 Lung Diseases Antibodies  >36 publications with BCA1 and Lung Diseases
 Brain Diseases Antibodies  >35 publications with BCA1 and Brain Diseases
 Vascular Diseases Antibodies  >25 publications with BCA1 and Vascular Diseases
 Hyperplasia Antibodies  >20 publications with BCA1 and Hyperplasia
 Kidney Diseases Antibodies  >20 publications with BCA1 and Kidney Diseases
 Recurrence Antibodies  >18 publications with BCA1 and Recurrence
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >194 publications with BCA1 and Lymph Node
 Spleen Antibodies  >86 publications with BCA1 and Spleen
 Lung Antibodies  >50 publications with BCA1 and Lung
 Skin Antibodies  >44 publications with BCA1 and Skin
 Kidney Antibodies  >28 publications with BCA1 and Kidney
 Muscle Antibodies  >24 publications with BCA1 and Muscle
 Intestine Antibodies  >23 publications with BCA1 and Intestine
 Thymus Antibodies  >22 publications with BCA1 and Thymus
 Stomach Antibodies  >10 publications with BCA1 and Stomach
 Extraembryonic Tissue Antibodies  >1 publications with BCA1 and Extraembryonic Tissue
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