NP_001035792.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-defensin 104
NCBI Official Synonym Full Names
defensin, beta 104B
NCBI Protein Information
beta-defensin 104; beta-defensin 4; defensin, beta 104
UniProt Protein Name
Beta-defensin 104
UniProt Synonym Protein Names
Beta-defensin 4; BD-4; DEFB-4; hBD-4; Defensin, beta 104
UniProt Synonym Gene Names
UniProt Entry Name
D104A_HUMAN
NCBI Summary for BD-4
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Jul 2008]
UniProt Comments for BD-4
Function: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Ref.1
Subcellular location: Secreted.
Tissue specificity: High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested. Ref.1
Induction: Antimicrobial activity is decreased when the sodium chloride concentration is increased.
Sequence similarities: Belongs to the beta-defensin family.
Research Articles on BD-4
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Pathways associated with BD-4 active protein
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