NP_005209.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-defensin 1 preproprotein
NCBI Official Synonym Full Names
defensin, beta 1
NCBI Protein Information
beta-defensin 1
UniProt Protein Name
Beta-defensin 1
UniProt Synonym Protein Names
Defensin, beta 1
UniProt Synonym Gene Names
UniProt Entry Name
DEFB1_HUMAN
NCBI Summary for BD1
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
UniProt Comments for BD1
defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.
Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: extracellular space; Golgi lumen; extracellular region
Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; response to bacterium; innate immune response in mucosa; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response
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Products associated with BD1 recombinant protein
Pathways associated with BD1 recombinant protein
Diseases associated with BD1 recombinant protein
Organs/Tissues associated with BD1 recombinant protein
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