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bFGF 2 recombinant protein :: BFibroblast Growth Factor-basic Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142165 bFGF 2 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BFibroblast Growth Factor-basic (bFGF 2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Bovine Fibroblast Growth Factor-basic

 Product Synonym Names    FGF 2 Bovine; Fibroblast Growth Factor-Basic Bovine Recombinant; HBGH-2; HBGF-2; Prostatropin; FGF-2; FGB-b
 Product Gene Name   

bFGF 2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Al a-Gly-Ser
 3D Structure    ModBase 3D Structure for P03969
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The FGF-b Bovine was lyophilized from a concentrated (1mg/ml) sterile solution containing 1% HSA.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Fibroblast Growth Factor-2 Bovine Recombinant in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.85 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).2. Analysis by RP-HPLC, using a calibrated solution of FGF-2 Bovine as a Reference Standard.
 Biological Activity    The ED50, measured in a mitogenic assay using quiescent NR6R-3T3 fibroblasts was found to be <0.1ng/ml, corresponding to a specific activity of 3 x 106 Units/mg.
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 Preparation and Storage    Lyophilized Fibroblast Growth Factor 2 Bovine although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-b Bovine Recombinant should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of bFGF 2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for bFGF 2 recombinant protein

   Description: FGF-2 Bovine Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of 17250 Dalton. The Fibroblast Growth Factor 2 is purified by proprietary chromatographic techniques.

Introduction: FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
 Product Categories/Family for bFGF 2 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Fibroblast Growth Factor
NCBI/Uniprot data below describe general gene information for bFGF 2. It may not necessarily be applicable to this product.
 NCBI GI #    27806627
 NCBI GeneID    281161
 NCBI Accession #    NP_776481.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174056.3 [Other Products]
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 UniProt Primary Accession #    P03969 [Other Products]
 UniProt Related Accession #    P03969 [Other Products]
 Molecular Weight    17,250 Da
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 NCBI Official Full Name    fibroblast growth factor 2
 NCBI Official Synonym Full Names    fibroblast growth factor 2 (basic)
 NCBI Official Symbol    FGF2 [Similar Products]
 NCBI Official Synonym Symbols   
FGF-2
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 2; BFGF; HBGF-2; basic fibroblast growth factor; heparin-binding growth factor 2
 UniProt Protein Name    Fibroblast growth factor 2
 UniProt Synonym Protein Names   
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
 UniProt Gene Name    FGF2 [Similar Products]
 UniProt Synonym Gene Names    FGF-2; bFGF; HBGF-2 [Similar Products]
 UniProt Entry Name    FGF2_BOVIN
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 UniProt Comments for bFGF 2    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis.
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 Research Articles on bFGF 2    1. Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA during these specific windows.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with bFGF 2 recombinant proteinPathways associated with bFGF 2 recombinant protein
 Reference Product  PubMed Publications
 FGFR1 recombinant protein  >713 publications with bFGF 2 and FGFR1
 FGFR2 recombinant protein  >366 publications with bFGF 2 and FGFR2
 FGFR3 recombinant protein  >152 publications with bFGF 2 and FGFR3
 PDGFRA recombinant protein  >135 publications with bFGF 2 and PDGFRA
 EGFR recombinant protein  >96 publications with bFGF 2 and EGFR
 FGFR4 recombinant protein  >68 publications with bFGF 2 and FGFR4
 IGF1R recombinant protein  >37 publications with bFGF 2 and IGF1R
 MMP2 recombinant protein  >33 publications with bFGF 2 and MMP2
 FN1 recombinant protein  >1 publications with bFGF 2 and FN1
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with bFGF 2 recombinant proteinOrgans/Tissues associated with bFGF 2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >983 publications with bFGF 2 and Nervous System Diseases
 Necrosis Antibodies  >618 publications with bFGF 2 and Necrosis
 Wounds and Injuries Antibodies  >576 publications with bFGF 2 and Wounds and Injuries
 Inflammation Antibodies  >444 publications with bFGF 2 and Inflammation
 Heart Diseases Antibodies  >419 publications with bFGF 2 and Heart Diseases
 Myocardial Ischemia Antibodies  >347 publications with bFGF 2 and Myocardial Ischemia
 Disease Progression Antibodies  >340 publications with bFGF 2 and Disease Progression
 Lung Diseases Antibodies  >325 publications with bFGF 2 and Lung Diseases
 Hyperplasia Antibodies  >258 publications with bFGF 2 and Hyperplasia
 Lung Neoplasms Antibodies  >226 publications with bFGF 2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2179 publications with bFGF 2 and Brain
 Skin Antibodies  >823 publications with bFGF 2 and Skin
 Liver Antibodies  >356 publications with bFGF 2 and Liver
 Ovary Antibodies  >219 publications with bFGF 2 and Ovary
 Adipose Tissue Antibodies  >194 publications with bFGF 2 and Adipose Tissue
 Intestine Antibodies  >132 publications with bFGF 2 and Intestine
 Mammary Gland Antibodies  >40 publications with bFGF 2 and Mammary Gland
 Uncharacterized Tissue Antibodies  >7 publications with bFGF 2 and Uncharacterized Tissue
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