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Bid recombinant protein :: BH3 Interacting Domain Death Agonist (Bid) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2012166 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BH3 Interacting Domain Death Agonist (Bid), Recombinant Protein

 Also Known As   

Recombinant BH3 Interacting Domain Death Agonist (Bid)

 Product Gene Name   

Bid recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD
 Chromosome Location    Chromosome: 22; NC_000022.10 (18216906..18257431, complement). Location: 22q11.1
 OMIM    601997
 3D Structure    ModBase 3D Structure for P55957
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Met1~Asp195 (Accession # P55957) with two N-terminal Tags, His-tag and T7-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of Bid recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Bid recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for Bid recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of Bid recombinant protein    Bid recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for Bid. It may not necessarily be applicable to this product.
 NCBI GI #    4557361
 NCBI GeneID    637
 NCBI Accession #    NP_001187.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001196.3 [Other Products]
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 UniProt Primary Accession #    P55957 [Other Products]
 UniProt Secondary Accession #    Q549M7; Q71T04; Q7Z4M9; Q8IY86 [Other Products]
 UniProt Related Accession #    P55957 [Other Products]
 Molecular Weight    25.8kDa
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 NCBI Official Full Name    BH3-interacting domain death agonist isoform 2
 NCBI Official Synonym Full Names    BH3 interacting domain death agonist
 NCBI Official Symbol    BID [Similar Products]
 NCBI Official Synonym Symbols   
FP497
[Similar Products]
 NCBI Protein Information    BH3-interacting domain death agonist; p22 BID; BID isoform Si6; BID isoform L(2); BID isoform ES(1b); desmocollin type 4; apoptic death agonist; Human BID coding sequence
 UniProt Protein Name    BH3-interacting domain death agonist
 UniProt Synonym Protein Names   
p22 BID; BIDCleaved into the following 3 chains:BH3-interacting domain death agonist p15; Alternative name(s):; p15 BIDBH3-interacting domain death agonist p13; Alternative name(s):; p13 BIDBH3-interacting domain death agonist p11; Alternative name(s):; p11 BID
 Protein Family    BH3-interacting domain death agonist
 UniProt Gene Name    BID [Similar Products]
 UniProt Synonym Gene Names    BID [Similar Products]
 UniProt Entry Name    BID_HUMAN
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 NCBI Summary for Bid    This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bid    BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: mitochondrial outer membrane; mitochondrion; membrane; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding; death receptor binding

Biological Process: caspase activation; release of cytochrome c from mitochondria; apoptosis; positive regulation of protein homooligomerization; positive regulation of apoptosis; DNA damage response, signal transduction; response to estradiol stimulus; regulation of cell proliferation; positive regulation of protein oligomerization; neuron apoptosis; apoptotic mitochondrial changes; induction of apoptosis via death domain receptors; brain development; protein targeting to mitochondrion; protein homooligomerization
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 Research Articles on Bid    1. Therefore, BID and BIM have nonoverlapping roles in the induction of apoptosis via BAK and BAX, affecting chemotherapy response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bid recombinant proteinPathways associated with Bid recombinant protein
 Reference Product  PubMed Publications
 CASP8 recombinant protein  >1130 publications with Bid and CASP8
 BAX recombinant protein  >1060 publications with Bid and BAX
 CASP3 recombinant protein  >977 publications with Bid and CASP3
 BCL2L1 recombinant protein  >335 publications with Bid and BCL2L1
 FADD recombinant protein  >200 publications with Bid and FADD
 BAK1 recombinant protein  >112 publications with Bid and BAK1
 FASLG recombinant protein  >59 publications with Bid and FASLG
 GZMB recombinant protein  >55 publications with Bid and GZMB
 MCL1 recombinant protein  >26 publications with Bid and MCL1
 Products by Pathway  Pathway Diagram
 Activation And Oligomerization Of BAK Protein Pathway antibodies  Activation And Oligomerization Of BAK Protein Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Diseases associated with Bid recombinant proteinOrgans/Tissues associated with Bid recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1714 publications with Bid and Neoplasms
 Cardiovascular Diseases Antibodies  >830 publications with Bid and Cardiovascular Diseases
 Necrosis Antibodies  >662 publications with Bid and Necrosis
 Lung Diseases Antibodies  >645 publications with Bid and Lung Diseases
 Gastrointestinal Diseases Antibodies  >612 publications with Bid and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >576 publications with Bid and Nervous System Diseases
 Pain Antibodies  >433 publications with Bid and Pain
 Heart Diseases Antibodies  >409 publications with Bid and Heart Diseases
 Adenocarcinoma Antibodies  >330 publications with Bid and Adenocarcinoma
 Diarrhea Antibodies  >320 publications with Bid and Diarrhea
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1770 publications with Bid and Blood
 Liver Antibodies  >548 publications with Bid and Liver
 Heart Antibodies  >502 publications with Bid and Heart
 Lung Antibodies  >495 publications with Bid and Lung
 Brain Antibodies  >354 publications with Bid and Brain
 Vascular Antibodies  >303 publications with Bid and Vascular
 Kidney Antibodies  >261 publications with Bid and Kidney
 Skin Antibodies  >227 publications with Bid and Skin
 Bone Antibodies  >200 publications with Bid and Bone
 Stomach Antibodies  >175 publications with Bid and Stomach
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