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BLC + BCA 1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539599 BLC + BCA 1 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BLC + BCA 1 (BLC + BCA 1), Recombinant Protein

 Also Known As   

Mouse BLC + BCA 1 protein

 Product Synonym Names    BLR1 Ligand protein; CXCL13 protein; BLC + BCA1; BLC + BCA-1 protein; BLC + BCA 1; BLC + BCA 1 protein; BLC + BCA-1
 Product Gene Name   

BLC + BCA 1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of BLC + BCA1 protein correspond ing to amino acids ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA.
 OMIM    605149
 3D Structure    ModBase 3D Structure for O43927
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 Host    Mouse
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes.
 Bioactivity    Determined by its ability to chemoattract Mouse B cells using a concentration of 10.0-100.0 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of BLC + BCA 1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BLC + BCA 1 recombinant protein

   Purified recombinant Mouse Mouse BLC + BCA 1 protein
 Product Categories/Family for BLC + BCA 1 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for BLC + BCA 1 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for BLC + BCA 1. It may not necessarily be applicable to this product.
 NCBI GI #    5453577
 NCBI GeneID    10563
 NCBI Accession #    NP_006410.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006419.2 [Other Products]
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 UniProt Primary Accession #    O43927 [Other Products]
 UniProt Related Accession #    O43927 [Other Products]
 Molecular Weight    9.8 kDa
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 NCBI Official Full Name    C-X-C motif chemokine 13
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 13
 NCBI Official Symbol    CXCL13 [Similar Products]
 NCBI Official Synonym Symbols   
BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 13
 UniProt Protein Name    C-X-C motif chemokine 13
 UniProt Synonym Protein Names   
Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
 UniProt Gene Name    CXCL13 [Similar Products]
 UniProt Synonym Gene Names    BCA1; BLC; SCYB13; BCA-1 [Similar Products]
 UniProt Entry Name    CXL13_HUMAN
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 NCBI Summary for BLC + BCA 1    B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
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 UniProt Comments for BLC + BCA 1    CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CCR10 chemokine receptor binding; CXCR5 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; lymph node development; positive regulation of integrin activation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response
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 Research Articles on BLC + BCA 1    1. After validation in larger patient groups, CXCR5 and CXCL13 may prove useful as biomarkers for nonsmall cell lung carcinoma Correspondingly, blockade of this axis could serve as an effective therapy for nonsmall cell lung carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BLC + BCA 1 recombinant proteinPathways associated with BLC + BCA 1 recombinant protein
 Reference Product  PubMed Publications
 CXCR5 recombinant protein  >199 publications with BLC + BCA 1 and CXCR5
 CXCL12 recombinant protein  >136 publications with BLC + BCA 1 and CXCL12
 CCL21 recombinant protein  >127 publications with BLC + BCA 1 and CCL21
 CCL19 recombinant protein  >101 publications with BLC + BCA 1 and CCL19
 CCR7 recombinant protein  >54 publications with BLC + BCA 1 and CCR7
 CXCL10 recombinant protein  >52 publications with BLC + BCA 1 and CXCL10
 CXCL9 recombinant protein  >31 publications with BLC + BCA 1 and CXCL9
 CXCR3 recombinant protein  >28 publications with BLC + BCA 1 and CXCR3
 CCL25 recombinant protein  >12 publications with BLC + BCA 1 and CCL25
 CCR10 recombinant protein  >2 publications with BLC + BCA 1 and CCR10
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with BLC + BCA 1 recombinant proteinOrgans/Tissues associated with BLC + BCA 1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >170 publications with BLC + BCA 1 and Inflammation
 Necrosis Antibodies  >63 publications with BLC + BCA 1 and Necrosis
 Disease Models, Animal Antibodies  >51 publications with BLC + BCA 1 and Disease Models, Animal
 Lung Diseases Antibodies  >33 publications with BLC + BCA 1 and Lung Diseases
 Carcinoma Antibodies  >32 publications with BLC + BCA 1 and Carcinoma
 Kidney Diseases Antibodies  >20 publications with BLC + BCA 1 and Kidney Diseases
 Hyperplasia Antibodies  >19 publications with BLC + BCA 1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >18 publications with BLC + BCA 1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >15 publications with BLC + BCA 1 and Liver Diseases
 Fibrosis Antibodies  >12 publications with BLC + BCA 1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >185 publications with BLC + BCA 1 and Lymph Node
 Spleen Antibodies  >82 publications with BLC + BCA 1 and Spleen
 Vascular Antibodies  >72 publications with BLC + BCA 1 and Vascular
 Bone Antibodies  >71 publications with BLC + BCA 1 and Bone
 Lung Antibodies  >45 publications with BLC + BCA 1 and Lung
 Kidney Antibodies  >24 publications with BLC + BCA 1 and Kidney
 Intestine Antibodies  >22 publications with BLC + BCA 1 and Intestine
 Muscle Antibodies  >21 publications with BLC + BCA 1 and Muscle
 Prostate Antibodies  >20 publications with BLC + BCA 1 and Prostate
 Pharynx Antibodies  >20 publications with BLC + BCA 1 and Pharynx
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