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BMP-10 recombinant protein

Scan QR to view Datasheet Catalog #    MBS691704 BMP-10 recombinant protein
Unit / Price
0.002 mg  /  $200 +1 FREE 8GB USB
0.01 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BMP-10, Recombinant Protein

 Also Known As   

Human BMP-10

 Product Synonym Names    BMP-10; Bone morphogenic protein 10
 Product Gene Name   

BMP-10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAE HLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV V TYKFKYEGM AVSECGCR
 Chromosome Location    Chromosome: 2; NC_000002.12 (68865481..68871517, complement). Location: 2p13.3
 OMIM    608748
 3D Structure    ModBase 3D Structure for O95393
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 Host    HEK 293 Cells
 Species Reactivity    Human
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 Purity/Purification    >95% by SDS-PAGE & HPLC analysis
 Form/Format    Lyophilized
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 Biological Activity    Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 4.0-6.0 ng/ml.
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 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of BMP-10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BMP-10 recombinant protein

   Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.  It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes.  BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.  Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
 Product Categories/Family for BMP-10 recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for BMP-10. It may not necessarily be applicable to this product.
 NCBI GI #    7656928
 NCBI GeneID    27302
 NCBI Accession #    NP_055297.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014482.1 [Other Products]
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 UniProt Primary Accession #    O95393 [Other Products]
 UniProt Secondary Accession #    Q53R17; Q6NTE0 [Other Products]
 UniProt Related Accession #    O95393 [Other Products]
 Molecular Weight    48,047 Da
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 NCBI Official Full Name    bone morphogenetic protein 10 preproprotein
 NCBI Official Synonym Full Names    bone morphogenetic protein 10
 NCBI Official Symbol    BMP10 [Similar Products]
 NCBI Protein Information    bone morphogenetic protein 10
 UniProt Protein Name    Bone morphogenetic protein 10
 UniProt Gene Name    BMP10 [Similar Products]
 UniProt Synonym Gene Names    BMP-10 [Similar Products]
 UniProt Entry Name    BMP10_HUMAN
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 NCBI Summary for BMP-10    The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP-10    Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Ref.4 Ref.5 Ref.6

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted

By similarity.

Tissue specificity: Detected in mammary epithelia (at protein level). Ref.6

Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines. Ref.6

Sequence similarities: Belongs to the TGF-beta family.
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 Research Articles on BMP-10    1. Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP-10 recombinant proteinPathways associated with BMP-10 recombinant protein
 Reference Product  PubMed Publications
 ACVRL1 recombinant protein  >9 publications with BMP-10 and ACVRL1
 TBX20 recombinant protein  >2 publications with BMP-10 and TBX20
 MYH6 recombinant protein  >1 publications with BMP-10 and MYH6
 SMARCA4 recombinant protein  >1 publications with BMP-10 and SMARCA4
 PARP1 recombinant protein  >1 publications with BMP-10 and PARP1
 ATF3 recombinant protein  >1 publications with BMP-10 and ATF3
 CDKN1C recombinant protein  >1 publications with BMP-10 and CDKN1C
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
Diseases associated with BMP-10 recombinant protein
 Disease Name  Pubmed Publications
 Vascular Malformations Antibodies  >3 publications with BMP-10 and Vascular Malformations
 Fibrosis Antibodies  >2 publications with BMP-10 and Fibrosis
 Dysostoses Antibodies  >1 publications with BMP-10 and Dysostoses
 Necrosis Antibodies  >1 publications with BMP-10 and Necrosis
 Inflammation Antibodies  >1 publications with BMP-10 and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with BMP-10 and Neoplasm Metastasis
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