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BMP7 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539456 BMP7 recombinant protein
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BMP7, Recombinant Protein

 Also Known As   

BMP7 protein

 Product Synonym Names    BMP 7 protein; BMP7; Bone Morphogenetic protein 7 protein; BMP-7; BMP-7 protein; OP-1 protein; BMP 7
 Product Gene Name   

BMP7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9H2W7
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures.
 Bioactivity    Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 ug/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    CHO cells
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of BMP7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP7 recombinant protein

   Purified recombinant Human BMP7 protein
 Product Categories/Family for BMP7 recombinant protein    Differentiation & Development
 Applications Tested/Suitable for BMP7 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for BMP7. It may not necessarily be applicable to this product.
 NCBI GI #    12003264
 NCBI GeneID    655
 NCBI Accession #    AAG43508.1 [Other Products]
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 UniProt Primary Accession #    Q9H2W7 [Other Products]
 UniProt Related Accession #    P18075 [Other Products]
 Molecular Weight    28.8 kDa
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 NCBI Official Full Name    bone morphogenetic protein 7, partial
 NCBI Official Synonym Full Names    bone morphogenetic protein 7
 NCBI Official Symbol    BMP7 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 7
 UniProt Protein Name    Bone morphogenetic protein 7
 UniProt Synonym Protein Names   
Bone morphogenetic protein 7
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP7 [Similar Products]
 UniProt Entry Name    Q9H2W7_HUMAN
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 NCBI Summary for BMP7    The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP7    BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: axon guidance; response to peptide hormone stimulus; negative regulation of MAP kinase activity; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; regulation of apoptosis; BMP signaling pathway; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; negative regulation of Notch signaling pathway; epithelial to mesenchymal transition; negative regulation of phosphorylation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth
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 Research Articles on BMP7    1. determined whether BMP-2, -6, and -7 differentially regulate the proliferation, mineralization, and mRNA expression of bone/mineralized tissue associated genes of human periodontal ligament stem cells obtained from periodontal ligament tissue
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP7 recombinant proteinPathways associated with BMP7 recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >119 publications with BMP7 and BMPR2
 SMAD5 recombinant protein  >43 publications with BMP7 and SMAD5
 BMPR1A recombinant protein  >36 publications with BMP7 and BMPR1A
 SMAD6 recombinant protein  >25 publications with BMP7 and SMAD6
 BMPR1B recombinant protein  >25 publications with BMP7 and BMPR1B
 ACVR1 recombinant protein  >24 publications with BMP7 and ACVR1
 ACVR2A recombinant protein  >6 publications with BMP7 and ACVR2A
 SOSTDC1 recombinant protein  >4 publications with BMP7 and SOSTDC1
 NOG recombinant protein  >4 publications with BMP7 and NOG
 FST recombinant protein  >3 publications with BMP7 and FST
 Products by Pathway  Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Organs/Tissues associated with BMP7 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1391 publications with BMP7 and Bone
 Kidney Antibodies  >212 publications with BMP7 and Kidney
 Embryonic Tissue Antibodies  >174 publications with BMP7 and Embryonic Tissue
 Connective Tissue Antibodies  >166 publications with BMP7 and Connective Tissue
 Muscle Antibodies  >118 publications with BMP7 and Muscle
 Brain Antibodies  >112 publications with BMP7 and Brain
 Mouth Antibodies  >92 publications with BMP7 and Mouth
 Eye Antibodies  >72 publications with BMP7 and Eye
 Heart Antibodies  >40 publications with BMP7 and Heart
 Lung Antibodies  >40 publications with BMP7 and Lung
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