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KCTD11 recombinant protein :: BTB/POZ domain-containing protein KCTD11 (KCTD11) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1341641 KCTD11 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $985 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $985 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,210 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,210 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,490 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,490 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,955 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,955 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BTB/POZ domain-containing protein KCTD11 (KCTD11), Recombinant Protein

 Also Known As   

Recombinant Human BTB/POZ domain-containing protein KCTD11 (KCTD11)

 Product Synonym Names    BTB/POZ domain-containing protein KCTD11
 Product Gene Name   

KCTD11 recombinant protein

[Similar Products]
 Product Synonym Gene Name    KCTD11; C17orf36; REN [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-232
 Sequence    MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH
 OMIM    609848
 3D Structure    ModBase 3D Structure for Q693B1
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KCTD11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for KCTD11. It may not necessarily be applicable to this product.
 NCBI GI #    51036594
 NCBI GeneID    147040
 NCBI Accession #    NP_001002914.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002914.2 [Other Products]
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 UniProt Primary Accession #    Q693B1 [Other Products]
 UniProt Secondary Accession #    B3KPE0 [Other Products]
 UniProt Related Accession #    Q693B1 [Other Products]
 Molecular Weight    29,875 Da
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 NCBI Official Full Name    BTB/POZ domain-containing protein KCTD11
 NCBI Official Synonym Full Names    potassium channel tetramerization domain containing 11
 NCBI Official Symbol    KCTD11 [Similar Products]
 NCBI Official Synonym Symbols   
REN; KCASH1; C17orf36; REN/KCTD11
[Similar Products]
 NCBI Protein Information    BTB/POZ domain-containing protein KCTD11; retinoic acid, EGF, NGF induced gene protein; potassium channel tetramerisation domain containing 11; retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11
 UniProt Protein Name    BTB/POZ domain-containing protein KCTD11
 Protein Family    BTB/POZ domain-containing protein
 UniProt Gene Name    KCTD11 [Similar Products]
 UniProt Synonym Gene Names    C17orf36; REN [Similar Products]
 UniProt Entry Name    KCD11_HUMAN
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 UniProt Comments for KCTD11    KCTD11: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm

Biological Process: negative regulation of neuroblast proliferation; regulation of growth; negative regulation of smoothened signaling pathway; protein ubiquitination; positive regulation of neuron differentiation; cell cycle; protein homooligomerization
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 Research Articles on KCTD11    1. the protein is expressed in two alternative variants: a short previously characterized form (sKCTD11) composed by 232 amino acids and a longer variant (lKCTD11) which contains an N-terminal extension of 39 residues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCTD11 recombinant proteinDiseases associated with KCTD11 recombinant protein
 Reference Product  PubMed Publications
 REN recombinant protein  >14 publications with KCTD11 and REN
 HDAC1 recombinant protein  >5 publications with KCTD11 and HDAC1
 GLI1 recombinant protein  >4 publications with KCTD11 and GLI1
 CUL3 recombinant protein  >3 publications with KCTD11 and CUL3
 SP1 recombinant protein  >2 publications with KCTD11 and SP1
 NEUROG1 recombinant protein  >1 publications with KCTD11 and NEUROG1
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >5 publications with KCTD11 and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with KCTD11 and Congenital Abnormalities
Organs/Tissues associated with KCTD11 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >6 publications with KCTD11 and Nerve
 Brain Antibodies  >6 publications with KCTD11 and Brain
 Blood Antibodies  >3 publications with KCTD11 and Blood
 Muscle Antibodies  >2 publications with KCTD11 and Muscle
 Heart Antibodies  >1 publications with KCTD11 and Heart
 Prostate Antibodies  >1 publications with KCTD11 and Prostate
 Lung Antibodies  >1 publications with KCTD11 and Lung
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